HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎关联性的Meta分析  

Meta-analysis on the association between HLA-DRB1*13 genetic polymorphism and chronic hepatitis B in Chinese Han population

作　　者：金安娜[1] 骆峻[1] 吴旭东[1] 陈轶玉[1] 马恩才[1] 

机构地区：[1]江苏职工医科大学医学微生物学教研室,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2006年第12期1288-1291,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:用Meta分析的方法综合评价HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎关联性。方法:检索中国生物医学文献数据库、维普数据库和Medline数据库,依据纳入与排除标准,收集所有相关的病例对照研究,应用RevMan4.2软件对符合条件的研究结果进行Meta分析。结果:符合纳入标准的共6篇文献,合计包含CHB组335例,正常对照组659例,经Egger’s检验未见显著发表偏倚。经综合分析:合并OR值为0.40,95%CI为0.21～0.79(P=0.008),认为HLA-DRB1*13等位基因是我国汉族人群慢性乙型肝炎发生的保护因素。结论:HLA-DRB1*13等位基因与我国汉族人群慢性乙型肝炎的发生具有统计学关联性,且为保护性基因。Objective：To assess the association of HLA-DRB1 ＊ 13 allele with chronic hepatitis B（CHB） in Chinese Han population. Methods：A comprehensive search for articles from 1998 to 2006 was conducted from CBMdisc, VIP database and Medline database. Six epidemioiogical case-control studies on the association between HLA-DRB1 ＊ 13 allele and CHB were collected and analyzed using RevMan 4.2 software. Results：A total of 335 CHB cases and 659 healthy controls from these 6 studies were involved.There was no evidence showing a publication bias after Egger＇s linear.regression analysis. The meta-analysis results showed that HLA-DRB1 ＊ 13 allele might be a protective factor against CHB, and the pooled odds ratio （OR） values was 0.40 （95%CI ：0.21-0.79,P = 0.008）. Conclusion：By meta-analysis, it is suggested that HLA-DRB1 ＊ 13 allele might be associated with the resistance to CHB in Chinese Han population.

关 键 词：慢性乙型肝炎 人类白细胞抗原Ⅱ HLA-DRB1＊13 基因多态性 META分析 

分 类 号：R512.62[医药卫生—内科学]