利用均匀设计筛选阿司匹林分散片处方  

SELECTION OF EXCIPIENTS FOR DISPERSIBLE ASPIRIN TABLETS BY UNIFORM DESIGN

作　　者：王卓[1] 韩丽梅[2,3] 张晓青 邓英杰[2,3] 张艳华 王越 

机构地区：[1]沈阳药科大学制药厂 [2]沈阳药科大学药物研究所 [3]东药集团沈阳红旗制药厂

出　　处：《沈阳药科大学学报》1996年第4期235-239,共5页Journal of Shenyang Pharmaceutical University

摘　　要：采用国产药用辅料，运用均匀设计方法对阿司匹林分散片处方进行筛选，给出三种崩解剂或溶胀性辅料占处方的比例分别为５％，７％，５％．经过对优选处方的实验表明：崩解时间小于３ｍｉｎ，分散均匀性试验能通过７１０μｍ筛网，均达到英国药典（１９９３年版）要求；体外溶出试验表明：Ｔ５０＝１．１６１ｍｉｎ，Ｔｄ＝２．１０９ｍｉｎ，与阿司匹林普通片溶出参数比较有显著差异，分散片溶出速度快，３０ｍｉｎ内几乎全部溶出．Using uniform design method,we selected Chinese make excipients for Dispersible Aspirin Tablets,and established three percentages of excipients:5%,7%,5%.The results show that:when disintegration time<3 min,uniforminty of dispersion is up to the standard of B.P.1993.The results of disollution are:T50=1.161min,Td=2.109min.The disollution rate of Dispersible Aspirin Tablets is faster than that of Aspirin Tablets.All parts of Aspirin in dispersible tablets are disolluted in about 30 min.

关 键 词：阿司匹林 分散片 均匀设计 处方筛选 溶出度 

分 类 号：R971.1[医药卫生—药品] R944.4[医药卫生—药学]