抑肽酶对体外循环心脏直视手术患者血液纤溶活性的影响  

EFFECTS OF APROTININ ON FIBRINOLYSIS AFTER CARDIOPULMONARY BYPASS IN CARDIAC OPERATION

作　　者：杨波[1] 周汉槎[1] 周伯通[1] 陈胜喜[1] 

机构地区：[1]湘雅医院心胸外科

出　　处：《湖南医科大学学报》1996年第6期573-575,578,共4页Bulletin of Hunan Medical University

摘　　要：将４８例先天性心脏病和风湿性心脏病患者分层后随机均分为四组。对照组不给抑肽酶，小、中、大剂量组分别给予抑肽酶１．５、３．０、６．０万ＫＩＵ·ｋｇ－１一次性加入预充液。用药组血浆中Ｄ－二聚体含量在体外循环（ＣＰＢ）末及术后１ｈ均较对照组明显减少（Ｐ＜０．０１），表明抑肽酶对ＣＰＢ过程中继发性纤溶亢进有一定的抑制作用。这可能为抑肽酶减少ＣＰＢ术后失血的机制之一。fter stratification,48 patients with heart,diseases were equally divided into four groups atrandom.Group C received no aprotinin(control),Group L,M and H received aprotinin 15000,30000 and 60000kIU·kg-1 resepectively.All the dosges were added to the pump prime all atonce before cardiopulmonary bypass(CPB).Although contents of D-dimers in four groups were much higher at the end of CPB and one hour postoperatively than in pre-CPB(P<0.01),theywere significantly less in aprotinin group than in control group.These results indicated that thesecondary hyperfibrinolysis had happened during CPB,and aprotinin had inhibited this processmarkedly,The inhibitory effect of aprotinin on fibrinolysis in CPB may be one of its mechanismsfor reducing blood loss of the patients after CPB.

关 键 词：心脏直视手术 血液纤溶活性 抑肽酶 体外循环 

分 类 号：R654.1[医药卫生—外科学]