硒蛋亚硒酸钠对云南克山病病区儿童全血谷胱甘肽过氧化物酶活性影响的动态观察  

Dpnamic observation of effect of Selenium-rich eggs and Sodium Selenite tablets on CSH-Px activity in blood of children in a Keshan disease area in Yunnan Province

作　　者：刘红[1] 路雪松[1] 于敬海[1] 万汇涓[1] 周强[1] 刘立志[1] 迟月明[1] 周葆初[1] 曾宪惠[1] 修智 

机构地区：[1]哈尔滨医科大学克山病研究所,哈尔滨医科大学化学教研室

出　　处：《中国地方病学杂志》1996年第6期338-340,共3页Chinese Jouranl of Endemiology

基　　金：国家"八五"攻关课题

摘　　要：选择云南楚雄克山病病区６～１０岁儿童作为观察对象，分为四组；服硒蛋组，服普通鸡蛋组．服亚硒酸钠药片组及对照组，连续３年动态观察将胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的活性，结果表明：服硒蛋组全血ＧＳＨ－ＰＸ活性显著增高，显著高于其它各组，服硒片组ＧＳＨ－ＰＸ的活性也增高，与服普通鸡蛋组、对照组比有差异，但不如服硒蛋组明显。结果提示：病区长期服硒蛋和硒片都能提高全血ＧＳＨ－Ｐｘ的活性，但服硒蛋比单纯服硒片效果更好。A three-years study was carried out on the effects of selenium-rich eggs, sodium selenite tablets and egga on GSH-Px activity in blood of 6-10 year - old children in Chuxong County, Yunnan Province,China,a Keshan disease area. Our results showed that GSH-Px activities in blood of children taking selenium-rich eggs and sodium selenite tablets were significantly higher than those in sera from egg-taking group and control group. Furthermore, the GSH-Px activity in blood of children taking selenium-rich eggs was even higher than that of sodium selenite-taking group. It is suggested that taking selenium-rich eggs and sodium selenite for a long period of time for children in endemic area can increase the GSH-Px activity in blood. Moreover,selenium-rich eggs may be more effective than sodium selenite tablets in increasing GSH-Px activity in blood of children in Keshan disease areas.

关 键 词：克山病 硒蛋 亚硒酸钠片 GSH-PX 预防 

分 类 号：R542.301[医药卫生—心血管疾病]