工作场所空气中奥克托今高效液相色谱测定方法研究  

Detemination of concentration HMX in workplace air by high performance liquid chromatography

作　　者：唐虹 汪冀 王延琦 夏宝清 

机构地区：[1]兵器工业卫生研究所科研三室,西安710065

出　　处：《中国卫生检验杂志》2006年第12期1409-1411,共3页Chinese Journal of Health Laboratory Technology

基　　金：2001年兵器工业集团总公司立项科研课题(42001100203)

摘　　要：目的：建立工作场所空气中奥克托今的高效液相色谱测定方法。方法：按照《工作场所空气中毒物检测方法的研制规范》的要求，进行实验室试验和验证试验及现场应用试验。结果：方法的检测限为0．81μg／ml（进样10μl洗脱液），最低检出浓度为0．017mg／m^3（以采集240L空气样品计）。当HMX含量为0—200．0μg／ml时，标准曲线线性关系良好。相关系数r=0．9999．高、中、低3个浓度的样品，6次重复测定，相对标准偏差为0．12％，1．30％，洗脱效率为94．88％～104．75％，方法的回收率为94．27％～102．05％，样品在室温至少可保存14d，奥克托今浓度为0．12，39，82mg／m^3，采样效率为91．20％～100．00％，工作场所空气中与奥克托今共存的三硝基甲苯、黑索今、二硝基甲苯，对奥克托今测定无干扰。结论：本方法各项指标达到《工作场所空气中毒物检测方法的研制规范》的要求，适用于工作场所空气中奥克托今的现场监测及样品纯度的检测。Objective：To establish the high performance liquid chromatography of HMX in workplace air. Methods：According to the demand of the Monitor Investigation Guidelines on Poisons in Workplace Air, investigation of laboratory and workplace was performed. Results： Detection limit for the method was 0- 81 μg/ml （ resent 10 μl eluent）. The lowest determining concentration was 0. 017 mg/m^3 （240 L air exemplar）. When HMX content was 0 - 200. 0 μg/ml, the calibration curve had a good linear relation. Coefficient of association r = 0. 999, use high hit and low concentration sample duplication determine 6 times, the relative standard deviation was 0. 12% - 1.30% ,the method selution efficiency was 94. 88% - 104.75% and the percent recovery was 94. 27% - 102.05% in the room temperature. The sample could conserve 14 days at least,the concentration of HMX was 0. 12 - 39. 82 mg/m^3 ,sampling efficiency was 91.20% - 100. 00% in workplace air,the concomitant of TNT RDX and DNT was nil interfere to the determination of HMX. Conclusion ：The index of method were all meet the requirement of the Monitor Investigating Guidelines on Poisons in Workplace Air. The method may be used in determining HMX in workplace air.

关 键 词：工作场所空气 奥克托令 时间加权平均容许浓度(TWA) 短时间接触容许浓度(STEL) 高效液相色谱法 

分 类 号：O657.72[理学—分析化学]