中药茵栀清肝汤对急性病毒性肝炎患者血清C-反应蛋白、超氧化歧化酶及丙二醛的影响  

Effects of Yinzhi Qinggan decoction on serum C-reactive protein,superoxide dismutase and malondialdehyde in patients with acute viral hepatitis

作　　者：宋仕玲[1] 朱艳[1] 刘章红[1] 黄团新[1] 甘雪婷[1] 

机构地区：[1]武警湖北总队医院传染科,武汉430061

出　　处：《武警医学》2006年第9期656-659,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的研究中药茵栀清肝汤对急性病毒性肝炎患者的治疗作用和对C反应蛋白、超氧化歧化酶及丙二醛的影响。方法80例急性病毒性肝炎患者随机分为对照组、还原型谷胱甘肽组和中药治疗低、高剂量组,中药组分别予以茵栀清肝汤1 g/kg、2 g/kg,1/d口服,共15 d。对照组、还原型谷胱甘肽组和中药治疗组均给予护肝治疗。治疗前后留取血清标本,检测肝功能;测定血清CRP、SOD及MDA的含量。结果中药茵栀清肝汤治疗组患者血清AST、ALT水平较对照组显著降低(P<0.05),对急性病毒性肝炎患者血清SOD活性有明显的升高作用(P<0.05),并降低血清CRP、MDA的含量(P<0.05)。上述各项指标在中药茵栀清肝汤高剂量治疗组与还原型谷胱甘肽组之间对比差异无统计学意义(P>0.05)。结论茵栀清肝汤具有治疗急性病毒性肝炎患者的作用,其机制可能和抗氧化应激反应,维护体内CRP、SOD及MDA平衡有关。Objective To investigate the effects of Yinzhi Qinggan decoction （YZ） on serum C - reactive protein, superoxide dismutase and malondialdehyde in patients with acute viral hepatitis.Methods Eighty patients with acute viral hepatitis were enrolled and randomly divided into four groups,20 each： control group, reduced glutathione group, low dose. YZ group and high dose YZ group. The control group was treated with conventional hepatoprotective therapy, while the reduced glutathione group, low dose YZ group and high dose YZ group were treated with reduced glutathione or Yinzhi Qinggan decoction 1 or 2 g/kg per day, respectively, and concumently with conventional hepatoprotective therapy. Sera of patients were collected before and after treatment for analysis. The effects and mechanism of Yinzhi Qinggan decoction were determined by liver function tests, C- reactive protein （CRP）, superoxide dismutase （SOD） and malondialdehyde （MDA） detennirnation. Results Morbid condition in all YZ treated patients was improved in a dose - dependent manner, and maximum effects were observed at a dose of 2 g/kg. Serum CRP, MDA, ALT and AST concentrations in YZ treated patients significantly decreased（ P 〈 0.05）; serum SOD concentration in YZ treated patients was significantly higher than that in control patients（ P 〈 0.05）.There were no significant differences in the above indices between the high dose YZ group and the reduced glutathione group （ P 〉 0.05）. Conclusions Yinzhi Qinggan decoction has protective effects on patients with acute viral hepatitis. It diminishes the severity of the liver injury by decreasing oxidative stress through its possible scavenging effect, and maintaining the equilibrium of CRO, SOD and MDA levels in the body.

关 键 词：茵栀清肝汤 急性病毒性肝炎 C-反应蛋白 超氧化歧化酶 丙二醛 

分 类 号：R563.101[医药卫生—呼吸系统]