国产加替沙星与左氧氟沙星双盲随机对照治疗细菌感染的Meta分析  

A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin

作　　者：张美和[1] 黄成华[1] 丁晓虎[1] 沈晓琴[1] 韩竹俊[1] 

机构地区：[1]南通大学医学院附属东台市第一人民医院,江苏东台224200

出　　处：《药学实践杂志》2006年第6期346-351,共6页Journal of Pharmaceutical Practice

摘　　要：目的：探讨国产加替沙星治疗细菌感染的有效性和安全性。方法：按照系统评价的要求全面检索了中国数字医院图书馆(www．chkd．cnki．net)、中国医学科学院的中国生物医学文献光盘数据库(CBM disk),对符合纳入标准的18篇文献共计2253名患者进行了Meta分析。结果：国产加替沙星组临床有效率与左氧氟沙星组临床有效率OR合并值1．42(95%CI为1．03～1．98),Z=2．11,P=0．03,差异有显著性；痊愈率、细菌清除率和不良反应发生率没有显著差异。结论：国产加替沙星治疗细菌感染的有效率比左氧氟沙星高。Objective ：To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection. Methods：According to the requirements of Cochrane systematic review, a tborough literature search was performed among Chinese digital Hospital Library （ www . cbkd , cnki . net ） and Chinese Biomedical Literature Disk Database （ CBM disk ）. A meta analysis was performed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria. Results ：The clinical effective rate of indigenous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups （ OR 1.42, 95% CI 1.03 - 1.98, Z = 2. 11 P = 0.03 ） have significant difference. Clinical cure rates, corresponding bacterial eradication rates and adverse reaction rates have no significant difference, Conclusions ： Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin ,

关 键 词：加替沙星 左氧氟沙星 双盲随机对照 细菌感染 META分析 

分 类 号：F407.7[经济管理—产业经济] R978.1[医药卫生—药品]