体质量指数与阻塞性睡眠呼吸暂停综合征时缺氧状态的关系  

Relationship between body mass index and anoxia in patients with obstructive sleep apnea syndrome

作　　者：李苏华[1] 石海英[1] 

机构地区：[1]上海市松江区中心医院呼吸内科,上海市201600

出　　处：《中国临床康复》2006年第48期194-195,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:分析体质量指数对阻塞型睡眠呼吸暂停综合征患者缺氧的影响。方法:于2004-06/2006-02选择上海市松江区中心医院呼吸内科收治的阻塞型睡眠呼吸暂停综合征患者63例,根据体质量指数分为肥胖组(38例)和非肥胖组(25例)。通过SW-SM2000C型多导睡眠监测仪测定平均血氧饱和度、最低血氧饱和度、发生血氧饱和度降低的总次数和每小时血氧饱和度降低的次数;比较两组偶发及持续的呼吸衰竭发生情况;并对体质量指数与呼吸暂停低通气指数的相关性进行直线回归分析。结果:纳入患者63例,均进入结果分析。①肥胖组平均血氧饱和度低于非肥胖组,血氧饱和度降低的总次数及每小时血氧饱和度降低次数两项指标均高于非肥胖组,差异均有显著性意义[分别为(90.08±3.06)%,(93.53±1.68)%;(376.68±180.93),(202.53±170.47)次;(45.97±18.92),(22.41±20.87)次,P<0.01]。两组之间最低血氧饱和度的差异无显著性意义。②两组患者偶发呼吸衰竭的发生无差异;肥胖组持续呼吸衰竭的发生高于非肥胖组,差异有显著性意义(分别为13,2例,P<0.05)。③体质量指数与呼吸暂停低通气指数呈正相关(r=0.4825,P<0.0005)。结论:体质量指数对睡眠呼吸暂停综合征患者的缺氧有明显影响。AIM： To analyze the effect of body mass index （BMI） on anoxia in patients with obstructive sleep apnea syndrome （OSAS）. METHODS： Sixty-three OSAS patients from June 2004 and February 2006 were selected from the Department of Respiratory Disease of Shanghai Songjiang Center Hospital and divided into the obesity group （n=38） and the non-obesity group （n=25） according to the BMI. The mean SaO2, the minimum SaO2, the total times of SaO2 dropped and the times of SaO2 dropped per hour were measured by SW-SM2000C type pelysomnograph （PSG）. The respiration failure that occurred occasionally and continuously were compared between the two groups. The Correlation between BMI and apnea-hypopnea index（AHI ）was analyzed by linear regression. RESULTS： A total of 65 enrolled subjects were involved in the analysis of results. ① The mean SaO2 was ohviously lower in the obesity group than that in the non-obesity group, whereas the total times of SaO2 drop and the times of SaO2 drop per hour were significantly were higher than those in the non-obesity group [ respectively were（90.08±3.06）%, （93.53±1.68）%; （ 576.68±180.95 ）, （ 202.55±170.47 ） ; （45.97±18.92 ）, （ 22.41±20.87 ）, P 〈 0.01]. However, there was no significant difference in the lowest SaO2 between the two groups. ② There was no difference in occasional respiration failure between the two groups, while continuous respiration failure took place more in the obesity group than that in the non-obesity group （which were respectively 13 and 2, P 〈 0.05）. ③ BMI was in positive correlation with AHI（r=-0.482 5 ,P〈0.000 5）.CONCLUSION： BMI makes a strong impact on the anoxia in patients with OSAS.

关 键 词：睡眠呼吸暂停 阻塞性 体重与身体测量 缺氧 

分 类 号：R845.22[医药卫生—航空、航天与航海医学]