血睾屏障开放调节机制研究进展  

Progress on Opening and Closing of the Blood-testis Barrier (BTB)

作　　者：袁小丽[1] 白汝岚[1] 刘姗姗[1] 张家骅[1] 

机构地区：[1]重庆市牧草与草食家畜重点实验室西南大学重庆动物科技学院,重庆400716

出　　处：《动物医学进展》2006年第12期31-34,共4页Progress In Veterinary Medicine

基　　金：教育部博士专项基金(20040625004)

摘　　要：血睾屏障是生精上皮中以支持细胞间的紧密连接为基础形成的结构,具有形成稳定的微环境和独特的免疫屏障,有序的开放机制保证了精子发生的顺利完成等功能。血睾屏障有序的开放是精子生成的保证,Oc-cludins,Claudins和JAMs这三种膜蛋白在调节血睾屏障的有序开放中发挥了重要作用,体内许多细胞因子和激素,如NO,TGF-β和TNF-α就是通过调节这几种蛋白的水平来调控血睾屏障的开放。尽管对血睾屏障的开放机制有了一定的认识,但目前还缺乏合适的体外模型,建立一种合适的体外模型是目前急需解决的问题。The blood-testis barrier （BTB） is comprised of the tight junction between the Sertoli cells,forming the stable microenvironment and special immunologic barrier to regulate the opening and closing of BTB. It is essential for normal opening and closing of BTB to assure the development of spermatogenic cell. In testis,occludins,claudins and JAMs was the important molecules relating to opening and closing of the BTB. Many cell factors and hormones in vivo, such as NO,TGF-β and TNF-α, regulate opening and closing of BTB through the proteins. Though the knowledge of the regulatory mechanism of BTB is increasing,it is an urgent issue to make the model in vitro.

关 键 词：紧密连接 血睾屏障 一氧化氮 转化生长因子 肿瘤坏死因子 

分 类 号：S852.16[农业科学—基础兽医学]