盐酸戊乙奎醚用于全麻术前减少腺体分泌的研究  

Clinical study on penehyclidine hydrochloride as premedication of general anesthesia

作　　者：严梅[1] 郭向阳[1] 叶铁虎[1] 肖涵[1] 吴新民[2] 贾乃光[3] 吴安石[4] 

机构地区：[1]中国医学科学院北京协和医院麻醉科,100730 [2]北京大学第一附属医院麻醉科 [3]北京中日友好医院麻醉科 [4]首都医科大学附属北京朝阳医院麻醉科

出　　处：《临床麻醉学杂志》2006年第11期827-829,共3页Journal of Clinical Anesthesiology

摘　　要：目的评价盐酸戊乙奎醚作为全麻术前用药减少腺体分泌的有效性与安全性。方法本研究采用多中心随机双盲平行对照观察。298例全麻病人随机分为三组,术前分别肌肉注射阿托品、盐酸戊乙奎醚或注射用水,测定注射后30min唾液分泌量。用视觉模拟评分(VAS)方法测定口干程度,记录不良反应。结果给药后30min,阿托品、盐酸戊乙奎醚和注射用水组唾液分泌量分别较给药前变化(-17·64±19·53)、(-22·30±21·04)和(2·71±19·46)mg。VAS阿托品、盐酸戊乙奎醚组用药后明显增加。给药后30min,阿托品、盐酸戊乙奎醚和注射用水组HR分别较给药前变化(1·65±8·82)、(-4·30±7·01)和(-0·54±6·49)次/分。观察期间无严重不良反应。结论盐酸戊乙奎醚作为全麻术前用药,可明显减少唾液分泌,无HR增快,无明显不良反应。Objective To evaluate the efficacy and tolerabillty of penehyelidine hydrochloride as premedication of general anesthesia. Methods Two hundreds and ninty-eight patients who will receive general anesthesia were randomly allocated into 3 groups： received penehyclidine hydrochlorlde （group A）, atropine（group B） or water（group C） injection intramuscular as premedication. The secretion of salivary gland and VAS of thirst were examined 30 rain after drug injection, and adverse events were evaluated. Results The salivary secretion significantly decreased in group A and B（P〈0. 05） after 30 rain of injection, which was not significantly different between the two groups. VAS of thirst significantly increased in group A and B （P〈0.05） after 30 min of injection, which was not significantly different between the two groups. The heart rate significantly decreased in group A and increased in group B （P 〈0.05） after 30 rain of injection. No serious adverse event was seen. Conclusion As premeditation, penehyclidine hydrochloride can be used effectively and safely to decrease the secretion of salivary gland without any increase in heart rate.

关 键 词：全身麻醉 抗胆碱药 盐酸戊乙奎醚 阿托品 唾液分泌 

分 类 号：R614.2[医药卫生—麻醉学]