妊高征与小于胎龄儿的相关性研究  

A case-control study of the association between gestational hypertension and risk of small for gestational age

作　　者：唐新意[1] 肖作源[1] 牟一坤[1] 张雪华[1] 陈裕明[2] 张建平[3] 

机构地区：[1]中山大学附属第三医院儿科,510630 [2]中山大学公共卫生学院医学统计与流行病学系 [3]中山大学附属第二医院妇产科

出　　处：《中国妇幼保健》2006年第23期3218-3221,共4页Maternal and Child Health Care of China

摘　　要：目的：探讨妊高征与小于胎龄儿（SGA）之间的联系。方法：选取2000年1月～2004年10月在本院出生的单胎活产SGA病例共834例（男443例，女391例）作为病例组。以胎儿性别及出生孕周进行频数匹配，按1：3的比例，采用完全随机抽样方法选取出生体重在10％～90％分位的适于胎龄儿2502例（男1329例，女1173例）为对照组，比较病例组及对照组新生儿母亲孕期患妊高征的比例。结果：①病例组母亲患轻度、中度及重度妊高征比例分别是对照组的2．52（95％CI，1．35—4．69）、4．21（2．03—8．70）和5．15（3．10—8．54）倍；②分层分析表明，男性及女性病例组母亲妊高征的患病比例分别是对照组的4．45（2．72—7．27）和3．51（2．14—5．75）倍，男性及女性病例组母亲妊高征的患病优势比无显著差异，早产和足月病例组母亲患妊高征的比例分别为对照组的9．96（4．50—22．02）和3．21（2．15—4．78）倍，早产病例组母亲妊高征的患病优势比显著高于足月病例组；③校正性别、足月与否及母亲年龄的多因素分析结果与单因素分析结果类似。结论：妊高征可显著增加SGA发病的危险性。Objective： The association between pregnancy - induced hypertension （PIH） and risk of small for gestational age （SGA） infant was assessed. Methods： SGA group included 834 （443 males and 391 females） singleton alive SGA deliveries in our hospital during january 2000 to October 2004. 2502 （1 329 males and 1 173 females） appropriate for gestational age （AGA） infants （ 1： 3, SGA/ AGA） matched by gender - and gestational - age - stratified frequencies of SGA were randomly selected for the controls from the infants with birth - weights ranged 10 th - 90 th percentiles. Ratios of maternal PIH between the case and control groups were compared. SGA was defined as sex - specific birthweight for gestational age that was equal to or less than 10th percentile cut - off of fetal growth reference of singleton alive infants delivered in our hospital during the period. Results： Univariate analysis showed that the ratios of mild, moderate and severe maternal PIH in the SGA group was 2. 52 （95% CI, 1.35 - 4. 69）, 4. 21 （2.03 - 8. 70） ＆ 5. 15 （3. 10 - 8. 54 ） folds higher than in the AGA group. The odds ratios （95%CI） for PIH in male and female infants were 4.45 （2.72 -7.27） ＆ 3.51 （2. 14 -5.75）, and in preterm and term sub -groups were 9. 96 （4. 50 -22. 02） ＆3. 21 （2. 15 -4. 78）, respectively. In the multivariate logistic analysis, such associations changed little after adjusting for maternal age, gestational age and infant＇s sex. Conclusion： The findings showed that PIH significantly increased the risk of SGA in a dose - dependent manner.

关 键 词：妊高征 小于胎龄儿 早产儿 

分 类 号：R714.246[医药卫生—妇产科学]