中药对血透患者营养不良-炎症综合征的影响  

The Effect of Chinese Medicine on MICS State of Dialysis Patients

作　　者：杨霓芝[1] 左琪[2] 桂定坤[2] 王立新[1] 包昆[1] 林启展[1] 刘旭生[1] 

机构地区：[1]广州中医药大学第二临床医学院,广州510120 [2]广州中医药大学

出　　处：《中国中西医结合肾病杂志》2006年第12期704-707,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：广东省重点科技攻关项目(No.2002C30804)

摘　　要：目的研究中药对慢性肾衰竭维持性血透患者营养不良-炎症反应综合征(MICS)的影响。方法MHD患者60例,随机分为治疗组和对照组各30例,治疗组在常规治疗中加入中药益气固肾液,对照组为常规血液透析液。观察治疗后患者血TNF-α、IL-6水平及营养指标(Alb、TF)。结果治疗组与对照组治疗后比较,血浆TNF-α水平明显下降(P<0.05),各项营养指标BW、TSF、AMC以及Alb、TF均提高(P<0.05)。结论中药益气固肾液能降低血浆TNF-α水平,提高BW、TSF、AMC以及Alb、TF水平,提示能改善维持性血透患者营养不良-炎症综合征。Objective：There is a vicious circle consisting of malnutrition and inflammation（MICS syndrome）associated with a high mortality rate in dialysis patients. Pro- inflammatory cytokines may play a central role in this scenario as an important cause to malnutrition and atherosclerosis. This study was purposed to investigate the affection of YiQiGuShen decoction on chronic inflammatory state of CRF. patients by detecting and comparing the biochemical indicators and TNF-α, IL-6 levels in patients of Maintain Hemodialysis （MHD） patients. Methods：60 cases of MHD patients were randomly allocated into two groups： treated group and control group, 30 cases in each. The period of the treatment was three months. Conventional dialysis liquid of sodium bicarbonate was used in the control group, while Yiqigushen decoction was added in the treated group. Results：TNF-α level in the treated group was lower than that in the control group with statistical significance （P〈0.05）, while the level of BW,TSF,AMC,Alb and TF in the treated grot,p was higher than that in the control group with statistical significance（ P〈0. 05）. Conclusion： Yiqigushen decoction could reduee the level of the TNF-α and improve the level of the BW ,TSF,AMC,ALB and TF. We thought that Yiqigushen decoction might improve the state of MICS syndrome.

关 键 词：慢性肾衰竭 维持性血液透析 营养不良-炎症综合征 益气固肾液 

分 类 号：R277.5[医药卫生—中医学]