系统性红斑狼疮患者CD5^+B细胞的测定和意义  

Change of peripheral blood CD5^+B cells in systemic lupus erythematosus patients

作　　者：黄文辉[1] 黄成辉[1] 陈瑞林[1] 陶怡[1] 

机构地区：[1]广州医学院第二附属医院风湿科,510260

出　　处：《中华风湿病学杂志》2006年第12期736-737,共2页Chinese Journal of Rheumatology

基　　金：广东省医学科研基金资助项目(A2000293)

摘　　要：目的探讨外周血中CD5+B细胞在系统性红斑狼疮(SLE)活动中的作用及相关性。方法利用流式细胞分析法对57例SLE患者和35名正常人群外周血CD5^+B细胞进行检测,并且同时检测抗dsDNA抗体、抗核抗体(ANA)、抗心磷脂抗体(ACL)、补体C3、C4。结果SLE患者CD5^+B细胞水平[(2．1+0．4)%]与正常人[(1．5±0．4)％]比较差异有统计学意义(P＜0．05),活动期SLE患者CD5^+B细胞水平(2．5±0．5)％显著高于稳定期(1．4±0．5)％；CD5+B细胞与dsDNA、ANA、抗心磷脂抗体(ACL)升高呈正相关,与补体c3呈负相关。结论系统性红斑狼疮患者外周血CD5^+B细胞明显升高,与SLE疾病活动有一定关系。Objective To explore change of peripheral blood CD5^＋Bcells in the systemic lupus erythematosus （SLE） patients and the association of this change with the disease activity. Methods The percentage of CD5^＋Bcells in peripheral blood in 57 patients with SLE and 35 healthy controls was determined by flow cytometry. Levels of anti-dsDNA, complement C3 and C4, anti-nuclear antibody（ANA）, anticardiolipin antibody （ACL）, were also measured. Results The percentage of CD5^＋B cell in SLE patients （2.1±0.4）% was higher than that in normal controls [（1.5±0.4）%] （P〈0.05）. In active disease group, the percentage of CD5^＋Bcells [（2.5±0.5）% ] was significantly higher than that in inactive SLE patients [（1.4±0.5）% ] （P〈0.01）. The percentage of CD5^＋B cell associated with anti-dsDNA, ANA, ALA positively, with C3 negatively and had no association with C4. Conclusion The percentage of CD5^＋B cells in the SLE is significantly high and has correlation and some relationship with the SLE.

关 键 词：红斑狼疮 系统性 CD5^+B细胞 

分 类 号：R593.241[医药卫生—内科学]