水飞蓟宾自微乳制剂的制备  

Preparation of Silibinin Self-Microemulsifying Preparation

作　　者：赵锦花[1] 许世信 孙多先[2] 

机构地区：[1]天津太平洋制药有限公司,天津300385 [2]天津大学化工学院,天津300072

出　　处：《天津大学学报》2006年第B06期39-41,共3页Journal of Tianjin University(Science and Technology)

摘　　要：为了提高水飞蓟宾生物利用度,制备了蓖麻油、丙二醇和聚氧乙烯(60)氢化蓖麻油组成的水飞蓟宾自微乳化浓缩物,它在水的存在下可自发形成平均粒径为57 nm的微乳．大鼠体内药物代谢动力学实验表明,该浓缩物的C_(max)=653．1 ng／mL,AUC_(0～12h)=2 468．6 h·ng/mL,明显高于原料的C_(max)=58．0 ng/mL,AUC_(0～12h)= 177．2 h·ng/mL．To increase the bioavailability of silibinin, silibinin self-microemulsifying concentration was prepared with castor oil, propylene glycol and polyoxyl（60） hydrogenated castor oil. It was self-microemulsified in water and the average size of the micelles was 57 nm. Pharmacokineties behavior in rats shows that Cmax and AUC0 - 12 h of the self-microemulsifying are 653.1 ng/mL and 2 468.6 h · ng/mL respectively, obviously higher than those of silibinin, whose Cmax and AUC0-12h are 58.0 ng/mL and 177.2 h . ng/mL respectively.

关 键 词：水飞蓟宾 微乳 自微乳化 

分 类 号：R944.9[医药卫生—药剂学]