252株耐药结核菌分析  

ANALYSIS FOR 252 STRAIN OF RESISTANCE MYCOBACTERIUM TUBERCULOSIS

作　　者：黄德强[1] 温贵华[1] 彭石潜[1] 卢谭旺[1] 何俊标[1] 

机构地区：[1]深圳市宝安区慢性病防治院,深圳518133

出　　处：《现代预防医学》2006年第12期2459-2460,共2页Modern Preventive Medicine

摘　　要：目的:分析宝安区结核病耐药情况。方法:2003年门诊就诊的结核病例,用罗氏培养基进行痰菌培养,选择培养阳性进行药敏试验。结果:初始耐药率顺位依次为:链霉素(67.5%)、异烟肼(50.4%)、乙胺醇(32.9%)、利褐平(25.0%)。对1种2种3种和4种药物初始耐药率分别为48.0%、29.4%、3.6%、9.9%,获得耐药率为4.0%、3.2%、0%、2.0%,常住人口耐药率为21.4%,暂住人口为78.6%。在46例耐多药病列中,常住人口耐多药率为26.1%,暂住人口为73.9%,暂住人口明显多过常住人口。耐药率男女之间没有显著差别。宝安区暂住人口40岁以下的成年人是结控工作的主要对象。结论:初始耐药病例是宝安区主要耐药病例,是结核病防治的新问题。Objective： To probe the resistance mycobacterium of circumstance in Baoan dlstrict.Methods： cultural examination by the L - J medium were applied to sputum of the clinic patients in 2003. Sensistility testing of anti - tuberculosis drugs was conducted for all isolated Colonies from pasitive sputum. Results： The initial drug resistance sequence of 252 strain were SM （67.5 % ）, INH （50.4%）, EMB （32.9%）, RFP （25.0%）. The resistance rate of one, two, three or four medicine were 48.0%, 29.4%, 3.6%, 9.9% in the initial drug resistance respectively and these were 4.0%, 3.2%, 0%, 2.0% in the acquired drug resistance respectively . In the 46 cases of MDR- TB, cases of the temporary household is more than the perpetual household. Resistance rate was 21.4%,6 in the perpetual household and was 78.6% in the temporary household. It is not signifcantly different beween male and female. Conclusion： Major cases of initial drug resistance in resistance tuberculosis patients were temporary household in the Baoan district. That is a new problem of tubrculosis prevention and control.

关 键 词：结核分支杆菌 耐药 

分 类 号：R378.911[医药卫生—病原生物学]