福辛普利联合美多洛尔对老年慢性心力衰竭患者血浆脑钠肽水平及TNF-α的影响  

THE INFLUENCE OF FOSINOPRIL AND METOPROLOL ON CHANGES OF PLASMA LEVEL OF BRAIN NATRIURETIC PEPTIDE AND TUMOR NECROSIS FACTOR-2 IN ELDLY CHRONIC HEART FAILURE

作　　者：吴锦晖[1] 张新军[1] 毛丽梅[1] 

机构地区：[1]四川大学华西医院干部科,成都610041

出　　处：《现代预防医学》2006年第12期2473-2474,2481,共3页Modern Preventive Medicine

摘　　要：目的：探讨福辛普利和美多洛尔对老年慢性心力衰竭患者血浆脑钠肽（BNP）和肿瘤坏死因子（TNF-α）的影响.方法：48例轻～中度慢性心力衰竭患者,随机分为福辛普利组26例和福辛普利联合美多洛尔治疗组22例,另选24例正常健康人为正常对照组.治疗前及治疗后6个月,分别测定上述各组的血浆BNP、TNF-α,应用超声心动图测定各组左室舒张末内径（LVEDd）和左室射血分数（LVEF）.结果：治疗前,慢性心力衰竭患者血浆BNP、TNF-α以及的功能测定值与正常对照组比较,差异具有统计学意义.治疗6个月后,心衰组的上述指标较各组治疗前差异有统计学意义;治疗6个月后比起福辛普利组,联合用药组BNP、TNF-α的下降更为明显,左室舒张末内径下降也更明显,左室射血分数的改善更为明显,差异均具有统计学意义.结论：心衰患者BNP、TNF-α水平与临床情况密切相关.心衰患者在常规治疗基础上加用美多洛尔,能进一步降低血浆BNP、TNF-α水平,改善左室重构和心功能.Objective： To observe on the influence of fosinopril and metoprolol on the changes of plasma level of brain Natriuretic peptide （BNP） and tumor necrosis factor - α （TNF- α） in eldly chronic heart failure . Methods： Plasma level of BN-P and TNF- α in 48 patients and 24 healthy controls were measured before treatment. Functional parameters were obtained by echocardiography. The heart failure group was further subdivided into either conventional or conventional plus metoprolol . The parameters were rechecked six mouths later.Results： The plasma BNP and TNF- α level in patients were significantly higher than these of healthy subjects （P〈0.05） . Six months later, the plasma BNP and TNF- α and heart function parameters significant different than those before treatment . Compared with patients with conventional treatment , the parameters in patients with conventional plus metoprolol had better heart function .Conclusion： Based on the conventional treatment , metoprolol can lower the circulating levels of BNP and TNF- α and can improve heart function .

关 键 词：老年慢性心力衰竭 脑钠肽 肿瘤坏死因子-α 福辛普利 美多洛尔 

分 类 号：R541.6[医药卫生—心血管疾病]