微波对烯酮和亚胺形成β-内酰胺顺反选择性的影响  

Effect of Microwave Irradiation on the Syn/Trans Selectivity in the Formation of β-Lactams From Ketenes and Imines

作　　者：王一恺[1] 杜大明[1] 许家喜[1] 

机构地区：[1]北京大学化学与分子工程学院生物有机与分子工程教育部重点实验室,北京100871

出　　处：《辽宁石油化工大学学报》2006年第4期94-95,99,共3页Journal of Liaoning Petrochemical University

摘　　要：为了确定微波照射对烯酮与亚胺反应形成β-内酰胺的顺反选择性的影响,通过核磁测定在相同反应温度下,传统加热与微波照射条件下由α-重氮乙酸苯硫酯生成的烯酮与亚胺形成的β-内酰胺的顺反比例,研究了微波对该反应的顺反选择性的影响。结果表明,微波对反应顺反选择性的影响并不十分明显,在非极性甲苯溶剂中略微有利于顺式产物的生成,在极性乙腈溶剂中则略微有利于反式产物生成。To study the effect of the microwave irradiation on the syn/trans selectivity in the formation of β- lactams from ketenes and imines, the syn/trans rations of β- lactams generated from imines and ketches yielded from S - phenyl 2 diazoethanethioate under classical heating and microwave irradiation conditions at the ,same temperature were determined via NMR. The effect of the microwave irradiation on the syn/trans ,selectivity in this reaction was investigated. The results indicate that the microwave irradiation affects the selectivity slightly. Cis products increase in nonpolar toluene and trans products increase in polar acetonitrile.

关 键 词：微波 烯酮 亚胺 Β-内酰胺 顺反选择性 

分 类 号：TQ02[化学工程]