甘露消毒丸与慢性肾小管间质肾病相关性的病例对照研究  

Case-control Study of Relationship between Chronic Tubulointerstitial Nephropathy and Ganluxiaodu Pills

作　　者：林凡[1] 许菲菲[1] 郑荣远[2] 吕吟秋[1] 刘毅[1] 黄陈平[3] 

机构地区：[1]温州医学院附属第一医院肾内科,温州325000 [2]浙江省神经流行病学研究中心温州医学院附属第一医院神经科 [3]温州医学院卫生学教研室

出　　处：《药物流行病学杂志》2006年第6期344-347,共4页Chinese Journal of Pharmacoepidemiology

基　　金：温州市科技发展计划项目(S2002A082)。

摘　　要：目的:探讨传统中成药甘露消毒丸是否为慢性肾小管间质肾病(CTN)的发病危险因素。方法:调查温州市几个大型社区居民,将资料登记完整及符合研究对象标准的652例进行非配比的病例对照研究。以均衡性检验比较病例组与对照组在性别、职业、年龄、受教育程度的构成,计算甘露消毒丸引起CTN的相对危险度,并计算暴露人群的归因分值及人群归因分值。结果:均衡性检验表明病例组与对照组患者的性别、年龄、受教育程度的构成没有统计学差异,职业构成有统计学差异。使用甘露消毒丸诱发慢性肾小管间质肾病的相对危险性(OR值)为37．08(P＜0．001),OR值95%可信区间(CI)为(13．16～104．49),经非条件logistic回归分析控制职业影响之后, OR值、95%CI值分别为58．53、17．25～198．59。暴露人群的归因分值为98．29%,人群归因分值57．98%。结论:甘露消毒丸是温州市慢性肾小管间质肾病的发病危险因素。推测与该药中的关木通含有马兜铃酸有关联。Objective： To verify whether ganluxiaodu pills （a traditional Chinese medicine containing caulis aristolochiae manshuriensts） is a morbid risk factor of chronic tubulointerstitial nephropathy（CTN）. Method： 652 residents in several districts were investigated. The odds ratio（OR） of CTN caused by ganluxiaodu pills were calculated by means of logistic regression analysis. All the data were analyzed by SPSS 12.0. Result： The homogeneity test showed there was no significant difference in age, sex, and education between the two groups, while there was significant difference in profession.The exposure to ganluxiaodu pills was screened as the valid risk factor of CTN with OR 37.08 （ P 〈 0.001 ） and OR 95% confidence interval（CI） ：13.16 - 104.49. After a non-conditional logistic regression analysis was done to control professions, the ORs were 58.53and 95% CIs of ORs were 17.25 - 198.59. The attribution fraction of the exposed population group was 98.29% and that of the whole population group was 57.98%. Conclusion： This case-control study indicated ganluxiaodu pills containing caulis aristolochiae manshuriensts was an independent risk factor of CTN in Wenzhou City. It might be related to aristolochic acid in ganluxiaodu pills.

关 键 词：甘露消毒丸 慢性肾小管间质性肾病 间质性肾炎 关木通 马兜铃酸 病例对照研究 

分 类 号：R969.3[医药卫生—药理学]