硫酸伪麻黄碱凝胶骨架型缓释片的制备与释放度试验  

Preparation and in vitro Release of Pseudoephedrine Sulfate Sustained Release Matrix Tablets

作　　者：王菲 

机构地区：[1]南京妇幼保健院药剂科,江苏南京210004

出　　处：《中国药业》2006年第20期33-34,共2页China Pharmaceuticals

摘　　要：目的研制硫酸伪麻黄碱缓释片并对其释放度的影响因素进行考察。方法以羟丙甲纤维素(HPMC)为骨架材料制备硫酸伪麻黄碱凝胶骨架型缓释片,采用紫外分光光度法测定体外硫酸伪麻黄碱,并对缓释片进行释放度试验。结果HPMC用量增加时释放速度变慢,磷酸氢钙用量增加时片剂可压性得以改善。结论该制剂缓释效果良好。Objective To prepare pscudoephedrite sulfate sustained reltase tablets and to study the faetors affecting release. Methods The sustained release tablets were prepared with HPMC by wetting granulation procedure. The analytical method in vitro of pseudoephedrine sulfate sustainedrelease tablets was set up and the effeel of difterent formulations on drug release was studied by determining the emnulative release. Results The release of a pseudoephedrine sulfate was mainly affected by the content of HPMC. The compressibility of the granule couhl be improved by calcium hydrogen phrephate. Conclusion Pseudoephedrine sulfate sustained- release tablets with appropriate release rate can be obtained through formulation optimization.

关 键 词：硫酸伪麻黄碱 缓释片 制备 释放度 

分 类 号：R944.9[医药卫生—药剂学] R927[医药卫生—药学]