宣肺平喘、温阳利水法对肺心病急性加重期合并周围性水肿患者抗利尿激素的影响  

Effect of "Dispersing Lung-qi and Relieving Asthma,Warming Yang to Induce Diuresis" Method on ADH of CPHD Patients during Acute Period with Peripheral Edema

作　　者：卢云[1] 张晓云[1] 黄宁[1] 陈绍宏[1] 

机构地区：[1]成都中医药大学附属医院,四川成都610072

出　　处：《中国中医药信息杂志》2006年第12期9-11,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：四川省中医药管理局重大项目(2003A15);四川省教育厅重点项目(2004C006)

摘　　要：目的对宣肺平喘、温阳利水法治疗慢性肺源性心脏病(CPHD)急性加重期合并周围性水肿疗效进行评价,并观察其对抗利尿激素(ADH)的影响。方法将CPHD急性发作期合并周围性水肿患者随机分为治疗组和对照组。治疗组采用中西医结合方案治疗,即在西医常规治疗基础上加以中药治疗,以宣肺平喘、化痰止咳、温阳利水为治法;对照组予西医常规加安慰剂治疗。2组均治疗14d。观察疗效性指标(总体疗效、中医主症积分、西医体征积分、血清电解质等)、机理性指标(ADH)。结果治疗组在总体疗效、改善症状体征、纠正电解质紊乱、纠正酸碱失衡等方面优于对照组。2组治疗后均无明显不良反应。治疗组在降低血清ADH水平方面优于对照组。结论针对肺心病急性发作期合并周围性水肿的中西医结合治疗可能具有提高总体疗效、改善症状体征、纠正电解质紊乱、纠正酸碱失衡等优势。同时,此治疗方法对ADH的分泌有一定抑制作用。提示抑制ADH分泌可能是宣肺平喘、温阳利水法治疗CPHD急性加重期合并周围性水肿的部分机理。Objective To evaluate the effectiveness of ＂dispersing lung-qi and relieving asthma, warming Yang to induce diuresis＂ method on CPHD patients during acute period with peripheral edema and observe the effect on ADH. Methods The CPHD patients during acute period with peripheral edema were randomly divided into treatment group and control group. The treatment group received Chinese medicine adding to regular westem medicine, the principle is dispersing lung-qi and relieving asthma, resolving phlegm to stop coughing, warming Yang to induce diuresis. The control group received placebo adding to regular westem medicine. Both of the groups were treated for 14 days. The effect observed indexes were as follows, general curative effect, integral of main symptoms of TCM, integral of westem medical signs, serum electrolyte, etc. Mechanism index was about ADH. Results The treatment group had better effects than the control group on the general curative effect, reducing integral of symptoms and signs, rectifying electrolyte and acid-alkaline-balance disturbances, etc. The safety analysis of two groups had no significant abnormality. Meanwhile, the treatment group had more superiority than the control group on reducing serum ADH. Conclusion The comprehensive treatment of traditional Chinese and westem medicine probably has more advantage in increasing the general effect, improving symptoms and signs, rectifying electrolyte and acid-alkaline-balance disturbances, etc. This therapeutic method can restrain secretion of ADH. It indicates that restraining secretion of ADH maybe part of the mechanism of using ＂dispersing lung-qi and relieving asthma, warming Yang to induce diuresis＂ method to treat CPHD patient during acute period with peripheral edema.

关 键 词：肺源性心脏病 周围性水肿 慢性阻塞性肺疾病 宣肺平喘 温阳利水 抗利尿激素 

分 类 号：R541.5[医药卫生—心血管疾病]