儿童单纯疱疹病毒感染血清学检查分析  

Serologic examination for childhood herpes simplex virus infection

作　　者：汤建萍[1] 杨于嘉[1] 张丹[2] 李梨萍[2] 

机构地区：[1]中南大学湘雅医院儿科,湖南长沙410008 [2]湖南省儿童医院,湖南长沙410007

出　　处：《中国当代儿科杂志》2006年第6期476-478,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的单纯疱疹病毒(HSV)感染是小儿时期常见的病毒感染,也是病毒性脑炎的常见病因,血清学检查是诊断HSV感染常用的检测方法。该文探讨儿童HSV感染的血清抗体检查的意义。方法采用ELISA方法检测2436例儿童血清中HSV-1和HSV-2的IgG和IgM抗体,并作回顾性分析。结果儿童单纯疱疹病毒血清抗体阳性率为44.6%(143/321),其中HSV-1抗体阳性率38.9%(117/301),HSV-2抗体阳性率15.9%(43/271);IgM阳性率为41.1%(132/321),IgG阳性率为25.5%(73/286);HSV-1血清阳性率随年龄而增加(P<0.01)。TORCH检测组HSV-2抗体血清阳性率1.9%,均为HSV-2IgG阳性。结论HSV血清学检查对儿童HSV感染具有重要的诊断意义。Objective This study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplexvirus （ HSV ） infection. Methods Serum samples were collected from 2 436 outpatients and inpatients. The samples were divided into two groups. Group 1 consisted of 321 samples which were assayed for HSV-1 lgG, HSV-1 lgM, HSV-2 lgG or HSV-2 lgM antibody using herpes simplex virus antibody kits between January 2003 and November 2005. Group 2 consisted of 2 115 samples which were assayed for HSV-2 IgG and lgM antibodies by TORCH testing between October 2004 and November 2005. Results In Group 1, the total seroprevalence of HSV infection was 44.6%, with 38.9% being HSV-1 positive and 15.9% HSV-2 positive; HSV-IgM positivity was found in 41. 1% and 25.5% were HSV-IgG positive; HSV-1 seroprevalence significantly increased with age （P 〈 0.05 ）. In Group 2 the seroprevalence of HSV-2 infection was 1.9% ; all of the samples were HSV-2 IgG positive. Conclusions HSV serologic examination is useful in the diagnosis of HSV infection in children.

关 键 词：单纯疱疹病毒 血清学检查 儿童 

分 类 号：R725.1[医药卫生—儿科]