国人原发性骨质疏松症诊断标准研究  

Study on the Diagnostic Criterion of Osteoporosis for Chinese

作　　者：沈霖[1] 杨艳萍[1] 谢晶[1] 周丕琪[1] 汤耿民[2] 赵光[3] 刘保平[1] 高兰[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院,武汉430022 [2]湖北省中医药研究院 [3]铁道部第四勘探设计院医院

出　　处：《实用医学进修杂志》2006年第4期198-202,共5页Journal of Practical Training of Medicine

摘　　要：目的：探讨适合我国人种特征的原发性骨质疏松症诊断标准。方法：以出生并生活在武汉市区的50-91岁居民820例为研究对象，用双能x线骨密度仪（DEXA）测量骨密度（BMD），分别以低于峰值BMD2．0s和2，5s为OP的诊断标准统计各年龄段OP的检出率；问卷结合X摄片调查骨折发生情况。结果：Ward＇s为OP检出的敏感部位。OP的发生率随年龄的增加而明显增高。如果采用WHO推荐的诊断标准，则OP的诊断界限在60～69岁年龄段，与骨折高发的年龄段相一致；而采用低于峰值骨量2.0s为诊断标准，则OP的诊断界限在50-59岁年龄段，不符合妇女骨衰老的生理特征，且较骨折高发的年龄段提前10年。结论：进行OP的流行病学筛选及临床诊断时。依据WHO的推荐骨质疏松症的诊断标准，即低于峰值骨量2.5S是适合我国人群特征的。Objective：To study the suitable diagnostic criterion of osteoporosis for Chinese. Methods： A total of 820 residents who were 50 - 91 yeas old in Wuhan area were selected randomly and participate the studies. Bone mineral density （BMD） was measured with Hologic 2000 plus energy X - ray absorptiometer （ DEXA）. Data of fractures were obtained by questionnaire and X - ray diagnosis. Results ： The detecting rate of OP at different sites was not the same and it was considerably higher at ward＇s triangle and than that another sites. The coincidence of osteoporosis increased with chronological age. If the diagnostic criterion of OP established by WHO was used, diagnostic limit of OP lied within 60 - 69 years old,and that is consistent with higher incidence aged of OP fracture. But if a value for BMD 2.0 s blow peak bone mass was used as diagnostic criterion of OP, the diagnostic limit of OP lied within 50 - 59 years old, which was obviosly not coincidence with physiology of bone metabolism in postmenopausal women. Conclusion： The criterion of 2.5 s blow the peak bone mass by WHO for diagnosing OP is suitable for Chinese.

关 键 词：骨质疏松症 诊断标准 

分 类 号：R681[医药卫生—骨科学]