葛根素抗衰老作用的研究  

Experimental Study on the Anti-aging Action of Puerarin

作　　者：钟星明[1] 江丽霞[1] 肖海[2] 刘春棋[1] 曾靖[2] 

机构地区：[1]赣南医学院第一附属医院,江西赣州341000 [2]赣南医学院基础医学院,江西赣州341000

出　　处：《时珍国医国药》2006年第12期2430-2431,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江西省卫生厅科研资助课题:赣卫科教字(No.20051129);赣南医学院科研课题(No.200512)

摘　　要：目的研究葛根素的抗衰老作用及机理。方法取SD大鼠40只,随机分为5组,生理盐水(老龄)对照组、小剂量(老龄)给药组、大剂量(老龄)给药组、VE(老龄)对照组,(少龄)对照组。给药4周,颈椎脱臼处死,检测心、脑、肝等组织中的SOD的活性和MDA的含量。结果葛根素对大鼠心、肝等组织中SOD活性显著升高,心、脑、肝等组织中MDA含量显著下降。结论葛根素具有抗衰老作用,其抗衰老作用的主要作用机制可能是提高SOD活性,降低MDA含量起作用的。Objective To study the anti - aging action and its mechanism of Puerarin. Methods 40 rats （SD） were randomly divided into 5 groups： normal saline control group,low dose Puerarin group, high dose Puerarin group,Vitamin E control group and young control group. The rats had been administered for 4 weeks and the activities of super oxide dismutase （SOD） and the levels of malondialdehyde （MDA） in hearts,brains and livers of rats were measured after the rats were killed . Results The activities of SOD obviously increased in hearts and livers and the levels of MDA decreased in hearts, brains and livers of Puerarin group rats. Conclusion Puerarin has anti - aging action and its mechanism maybe related to the increase of the SOD activity and the decrease of MDA level.

关 键 词：抗衰老 超氧化物歧化酶 丙二醛 葛根素 

分 类 号：R285.5[医药卫生—中药学]