大庆市先天性甲状腺功能减低症筛查  

Screening of congenital hypothyroidism in Daqing

作　　者：潘建玲[1] 陈玉梅[1] 张凤侠[1] 蒋丽鑫[1] 李志波[1] 

机构地区：[1]哈尔滨医科大学附属第五临床医学院检验科,黑龙江大庆163316

出　　处：《中国优生与遗传杂志》2006年第12期90-90,19,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨大庆地区新生儿先天性甲状腺功能减低症的发病率，是为了早发现早治疗，减少儿童致残率，提高本地区人口素质。方法以大庆地区出生的新生儿为筛查对象，于出生后48-72h，充分哺乳后采取足跟血，应用酶联免疫法（ELISA）检测标本中促甲状腺素（TSH）含量，TSH≥10mIU／L为初筛临界值，以血清TSH、血清游离三碘甲状腺原氨酸（FT3）和血清游离甲状腺素（FT4）浓度确诊。结果2004年1月至2005年12月2年期间共筛查32524例，确诊先天性甲状腺功能减低症患儿10例，结果（x^-±s）纸片法TSH69．89±23．79，血清TSH85．18±15．62，FT3 7．32±2．69，FT4．25±1．34。其中男2例、女8例，发病率为万分之3．07（5／16262）。结论大庆市测得甲状腺功能减低症发病率为万分之3．07，高于国、内外其他地区报道。早发现早治疗可避免患儿的智力障碍，对提高我国人口素质有着十分重要的意义。Objective： The incidence of neonatal CH （Congenital hypothyroidism） in Daqing region is explored in order to diagnose and treat in the early stage, reduce the children＇s handicap rate and enhance the diathesis of the population in the region. Methods： The newborns in Daqing region were chosen as the screening objects and were sampled the heel blood from after sufficient suckling when they were 48 - 72 hours old. The concentrations of TSH （ Thyrotropin - stimulating hormone） in the samples were detected by ELISA （enzyme linked immunosorbent assay） with a critical value of TSH ≥ 10mIU/L for the first screening and the diagnosis was made according to the concentrations of serum TSH, FT3 （free triiodothyronine） and FT4 （free thyroxine）. Results： 32524 newborns were screened from January of 2004 to December of 2005, and ten cases were diagnosed. The results showed that the hlood of paper （ x^-± s ） TSH was 69. 89 ±23.79, serum TSH was 85.18 ± 15.62, FT3 was 7. 32 ±2.69, and FT4 was 4. 25 ± 1.34. The diagnosed cases included 2 males and 8 females and the incidence is 0. 307 thousandth. Conclusion： The incidence of CH in Daqing is 0. 307 thousandth, higher than those reported for other regions. The diagnosis and treatment in the early stage may avoid the children＇s handicap in intelligence, and are significant for enhancing the diathesis of the population of our country.

关 键 词：新生儿筛查 甲状腺功能减低 发病率 

分 类 号：R725.8[医药卫生—儿科]