2─羟甲基─3，5，6─三甲基吡嗪的合成及其对血液流变性的影响  

Synthesis of 2 Hydroxymethyl 3,5,6 Trimethyl Pyrazine and Observation of its Affection on Rheologic Parameters

作　　者：陈学敏[1] 许淑菊[1] 马永雯 

机构地区：[1]西安医科大学药学系药物化学教研室

出　　处：《中国药物化学杂志》1996年第4期254-256,共3页Chinese Journal of Medicinal Chemistry

摘　　要：合成了川芎嗪体内主要代谢产物２－羟甲基－３，５，６－三甲基吡嗪．以川芎嗪为阳性对照观察了它对血液流变性的影响。2 Hydroxymethyl 3,5,6 trimethyl pyrazine was synthesized.It is the essential intracorporal metabolite of tetramethyl pyrazine.Tetramethyl pyrazine was taken for positive control and compared among them on its rheologic parameters.It was found that both drugs showed no significant difference.

关 键 词：川芎嗪 羟甲基 三甲基吡嗪 血液流变性 

分 类 号：TQ463.5[化学工程—制药化工] R965[医药卫生—药理学]