脂蛋白脂酶在胰岛素抵抗和动脉粥样硬化的发病中的矛盾作用  

The Contradictive Effects of Lipoprotein Lipase in Insulin Resistance and Atherogenesis

作　　者：葛光岩[1] 姚福梅[2] 

机构地区：[1]大连市第二人民医院内分泌科,辽宁大连116011 [2]大连市第二人民医院心内科,辽宁大连116011

出　　处：《医学综述》2006年第23期1431-1433,共3页Medical Recapitulate

摘　　要：脂蛋白脂酶为甘油三酯代谢的限速酶,脂蛋白脂酶因活性和含量而改变其脂解功能,影响全身脂质代谢和分布,产生的血脂紊乱、高甘油三酯血症、低HDL血症是胰岛素抵抗和动脉硬化的基础。同时,脂蛋白脂酶对动脉粥样硬化和胰岛素抵抗形成具有截然不同的矛盾作用。Lipoprotein lipase （LPL） is the rate-limiting enzyme in metabolism of triglyeeride. Its changes in activity and co,tent can affect its stearolysis function and the lipid metabolism and distribution in whole body ,which then resulted in blood fat disorder, hypertriglyceridemia and low level of HDL. These are all the basis of insulin resistnaee and atherogenesis. Meanwhile, LPL has contradietive effect in the genesis of thses two pathological process.

关 键 词：脂蛋白脂酶 胰岛索抵抗 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]