漫反射FT-IR和单晶XRD法研究盐酸林可霉素多晶型  

Utilization of fourier transform-infrared spectroscopy and X-ray diffraction of single crystal for the study of two crystal forms of lincomycin hydrochloride

作　　者：杨梁[1] 张敏[1] 鹿颐[1] 张克勤[2] 王丽艳 

机构地区：[1]河北省药品检验所,石家庄050011 [2]燕山大学材料科学与工程学院,秦皇岛066004 [3]秦皇岛市药品检验所,秦皇岛066000

出　　处：《药物分析杂志》2006年第11期1562-1565,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:研究盐酸林可霉素2种晶型晶体结构中不同分子构象对其漫反射红外光谱行为的影响。方法:单晶 X 射线衍射法、傅立叶变换漫反射红外光谱法。结果:盐酸林可霉素2种晶型分属不同晶系及空间群。它们在晶胞中的分子内、分子间氢键与分子构象不同,从而造成其漫反射红外光谱行为的显著差别。结论:可用傅立叶变换红外漫反射光谱法鉴别盐酸林可霉素2种晶型。Objective： To study the influences of different molecular conformations and hydrogen bond in the different lincomycin hydrochloride crystal structures on their behaviour of diffuse reflection fowrier transform infrared spectrum. Methods ：X- ray diffraction of single crystal, diffuse reflection fourier -transform infrared spectroscopy were used. Results： Crystal formⅠ and crystal form Ⅱ belong to different crystal systems and space groups. Differences of two molecular conformations and hydrogen bonds of intra - and inter - molecdulars contribute to significant different behaviour of their FT - IR spectroscopy. Conclusion： The method can be used to identify the crystal form Ⅰand crystal form Ⅱ of lincomycin hydrochloride by FT - IR spectroscopy.

关 键 词：盐酸林可霉素 多晶型 分子构象 单晶X射线衍射法 漫反射傅立叶变换红外光谱法 

分 类 号：R917[医药卫生—药物分析学]