海洋来源真菌A-f-11中吲哚二酮哌嗪类抗肿瘤活性成分的研究  

Studies on the indolyl diketopiperazine analogs produced by marine-derived fungus A-f-11

作　　者：赵文英[1] 张亚鹏[1] 朱天骄[1] 方玉春[1] 刘红兵[1] 顾谦群[1] 朱伟明[1] 

机构地区：[1]海洋药物教育部重点实验室中国海洋大学海洋药物与食品研究所

出　　处：《中国抗生素杂志》2006年第12期749-752,764,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.30470196);国家863计划基金(2003A624020);山东省和青岛市自然科学基金(No.Z2001C01&04-2-JZ-81)

摘　　要：对海洋来源具有抗肿瘤活性的真菌A-f-11中活性次级代谢产物进行了研究,采用活性追踪的方法从乙酸乙酯提取物中分离得到7个含吲哚基的二酮哌嗪类化合物,根据化合物的光谱特征和理化性质分别鉴定为cyclo-L-tryptophyl-L-proline(1),N-Prenyl-cyclo-L-tryptophyl-L-proline(2),tryprostatin B(3),dem ethoxyfum itrem orgin C(4),fum it remorgin C(5),cyclotrypros-tatins B(6)和fum itrem orgin B(7),其中化合物2为新天然产物。利用丽丝胺罗丹明法,对7个单体化合物的抗肿瘤活性进行了初步评价。To investigate the antitumor secondary metabolites of marine-derived fungal A-f-11. Seven indolyl diketopiperazine compounds were isolated with bioassay-guided separation procedure. The structures of these compounds were determined through extensive analysis of 1D and 2D-NMR data. Their antitumor activities against K562 cell lines were preliminarily evaluated by the lissamine rhodamine B method. Compound 2 was a new natural product.

关 键 词：海洋来源真菌 吲哚二酮哌嗪 抗肿瘤活性 

分 类 号：R979.1[医药卫生—药品]