锂处理中国地鼠糖尿病模型肝的变化  

Alteration of hepatic tissue from lithium treated diabetic model of Chinese hamster

作　　者：吴杨松[1] 胡敏[1] 李代强[1] 伍汉文[1] 

机构地区：[1]湖南医科大学第二临床医学院代谢内分泌研究所,广西北海市人民医院内科

出　　处：《中国糖尿病杂志》1996年第4期218-221,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金

摘　　要：用小剂量碳酸锂处理糖尿病模型中国地鼠（ＮＩＤＤＭ）６个月后，观察肝组织的形态学和锂含量变化以及锂盐治疗糖尿病的疗效。结果显示：糖尿病中国地鼠肝组织缺锂（Ｐ＜０．０５），存在明显的病理学改变；锂处理后，糖尿病鼠血糖、果糖胺下降（Ｐ＜０．０５），胰岛素无变化，肝锂含量增高，肝糖原增多，肝病理改善。提示：锂的降糖作用，可能是通过肝组织──糖代谢的重要器官之一实现的。The morphological and lithium content alteration of hepatic tissue as well as effect of lithium on diabetes after six months of administration of low-dosage lithium carbonate to diabetic models of Chinese hamster were observed.The data revealed①remarkable lithium deficiency and pathologic changes of hepatic tissues in untreated diabetic Chinese hamsters;and ②after lithium decrease of blood glucose and fructosamine level(P<0.05),no remarkable change of insulin level and increase of lithium content together with pathologic improvement in liver.The results indicated that the hypoglycemic effect of lithium might result from improvement in insulin sensitivity of target tissues,especially of the liver──one of the most important organs related to glucose metabolism.

关 键 词：糖尿病 动物模型 中国地鼠 碳酸锂 

分 类 号：R587.1[医药卫生—内分泌] R971.43[医药卫生—内科学]