石油沥青毒性及致突变性实验研究  

An experimental study on toxicity and mutagenicity of petroleum asphalt

作　　者：慈捷元[1] 

机构地区：[1]深圳市疾病预防控制中心,广东深圳518020

出　　处：《中国职业医学》2006年第6期426-428,共3页China Occupational Medicine

基　　金：卫生部标准研究资助项目(编号3-92-098)

摘　　要：目的为制订职业卫生标准补充实验研究资料。方法通过石油沥青急性经口毒性、亚慢性吸入毒性及遗传毒性的实验研究,观察在该实验条件下,石油沥青对受试动物的影响。结果实验动物体重、WBC、Hb、尿素氮(BUN)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、染色体畸变率、骨髓细胞微核检出率没有明显变化,但可引起支气管炎和肺气肿。结论石油沥青一般毒性低,无致突变性,加温产生的挥发性物质对呼吸系统有较强的刺激作用。Objective To supply experimental data for establishing occupational hygienic standard. Methods Acute oral toxicity test, subchronic inhalation toxicity test and mutagenieity test were conducted to observe the effects of petroleum asphalt in experimental animals. Results The body-weight of experimental animals , and WBC, Hb, BUN, ALT, AST, ALP and the rates of chromosome aberration and micronuclei didn＇ t change obviously, but bronchitis and pulmonary emphysema were found in pathological examination. Conclusion Petroleum asphalt is a low-toxic substance, and the mutagenicity is not found in the animal experiment, but stimulation of petroleum asphalt fume on respiratory system is quite obvious.

关 键 词：石油沥青 毒性 实验研究 致突变性 

分 类 号：R135.1[医药卫生—劳动卫生] R994.3[医药卫生—公共卫生与预防医学]