苦参碱白蛋白微球的制备及性质  

Preparation and Characterization of Matrine Albumin Microspheres

作　　者：邹东娜[1] 张典瑞[1] 张学顺[2] 席延伟[1] 

机构地区：[1]山东大学药学院药剂教研室,山东济南250012 [2]山东中医药大学附属医院药剂科,山东济南250011

出　　处：《中国医药工业杂志》2006年第12期824-827,共4页Chinese Journal of Pharmaceuticals

摘　　要：以乳化-化学交联法制备苦参碱白蛋白微球。采用扫描电镜、差示扫描量热法和X-射线衍射法考察微球的特性,并用动态透析法考察体外释药规律。所得微球外观圆整,包封率为(83.55±3.17)%,载药量为(6.19±0.24)%,平均粒径(0.94±0.15)μm。体外释放试验结果显示,苦参碱白蛋白微球具有明显的缓释作用。Matrine albumin microspheres were prepared by emulsion-chemical cross linking method. The scanning electron microscope, differential scanning calorimetry and X-ray diffraction were utilized to investigate the characteristics of the microspheres. The results showed that the microspheres were spherical with the entrapment efficiency of （83.55±3.17） %, the drug loading of （6.19 ±0.24） %, and mean particle size of （0.94 ± 0.15） μm. The in vitro release behavior was carried out by dynamic dialysis to indicate that the microspheres had significant sustained-release effect.

关 键 词：苦参碱 白蛋白微球 体外释药 

分 类 号：R944.9[医药卫生—药剂学]