抗心磷脂抗体阳性患者血栓危险因素的相关性研究  

Analysis of Risk Factors in the Development of Thrombosis in Patients with Anticardiolipin Antibodies

作　　者：陶赞英[1] 莫汉有[2] 黄熙[3] 郑明慈[1] 

机构地区：[1]广西省桂林医学院附属医院临床医学研究中心,桂林541001 [2]广西省桂林医学院附属医院血液科,桂林541001 [3]广西省桂林医学院附属医院皮肤性病科,桂林541001

出　　处：《血栓与止血学》2006年第6期252-253,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨抗心磷脂抗体阳性患者血栓形成的危险因素。方法将103例抗心磷脂抗体阳性患者按是否发生血栓事件分为两个组,对相关因素进行回顾性分析研究。结果发生血栓事件患者占47．57％(49/103),与无血栓事件患者对照,其年龄明显大于对照组(P＜0．01)；两组在性别、民族、高血压病、糖尿病、高脂血症及吸烟方面差异无显著性(P＞0．05)。抗心磷脂抗体IgG及IgM均阳性在血栓组有较高的频率,与对照组相比差异有显著性(P＜0．01)。结论年龄大,抗IgG抗体及抗IgM抗体均阳性是抗心磷脂抗体阳性患者易并发血栓事件的危险因素。Objective To explore the risk factors in the development of thrombosis in patients with anticardiolipin antibodies（aCA）. Methods One hundred and three patients with aCA were divided into two groups according to whether patients with a thrombotic event or not. The potential risk factors were analyzed retrospectively. Results Of the 103 patients with aCA, 49 had a thrombotic event. The patients with thrombosis were significantly older than patients without thrombosis（P 〈 0.01 ）. No significant differences in gender, race, HTN, DM, hyperlipidaemia, tabacco use in the two groups. Thrombosis was more frequent in patients who were seropositive for both lgG and IgM （ P 〈 0.01 ）. Conclusion Older age with a single aCA determination and both IgG and IgM aCL determination are the risk factor for thrombosis.

关 键 词：抗心磷脂抗体 血栓 危险因素 

分 类 号：R593.2[医药卫生—内科学]