传统CAV方案与金喜素联合顺铂治疗小细胞肺癌疗效回顾对比分析  

Comparison of curative effects of traditional CAV scheme with Topotecan hydrochloride and Cisplatin for small cell lung cancer

作　　者：傅恩清[1] 金发光[1] 孙亚妮[1] 刘春丽[1] 刘静莉[1] 楚东岭[1] 刘同刚[1] 谢永宏[1] 

机构地区：[1]第四军医大学唐都医院呼吸科,陕西西安710038

出　　处：《现代生物医学进展》2006年第11期58-59,共2页Progress in Modern Biomedicine

摘　　要：目的:分组比较传统CAV方案(环磷酰胺+阿霉素+长春新硷)和金喜素和顺铂方案对小细胞肺癌患者的治疗效果。方法:通过分组对比分析164例小细胞肺癌患者连续三次应用传统CAV(环磷酰胺、阿霉素、长春新硷)方案和连续三次应用金喜素联合顺铂方案化疗,检测肿块横径与直径缩小程度,比较两个方案对小细胞肺癌的治疗作用。结果:金喜素联合顺铂方案时小细胞肺癌总有效率迭56．5％,传统CAV方案总有效率41．8％,两组比较有明显统计学意义(x2=18．4>16．27,v=3,p<0．001),两组毒副反应比较无统计学意义(x2=5．62<9．49,v=4,p>0．05)。结论:金喜素联合顺铂方案时小细胞肺癌较传统CAV方案有更明显的疗效,值得临床应用。Objective： To observe the curative effect of traditional CAV（Cyclophosphamide,Adriamycin,Vincrisdne） scheme or Topotecan hydrochloride and Cisplatin for 164 patients with small cell lung cancer （SCLC）. Methods： Eighty four patients were treated with Topotecan hydrochloride and Cisplatin and seventy nine patients,with traditional CAV .The transverse diameter and anteroposterior diameter of tumor were measured,and the the therapeutic effects of the two schemes for SCLC were compared.The differences between the two groups were analysed. Results： The total effective rate was 56.5% in the group with Topotecan hydrochloride and Cisplatin chemotherapy and 41.8%, in the group with traditional CAV. There was significant statistical difference between the two groups （ x^2=18.4〉 16. 27, v=3,p〈0.001）,without statistid difference of toxic effect and side-effect （x^2=5.62 〈9.49, v=4, p〉0.05）. Conclusion： Topotecan hydrochloride with Cisplatin is more effective than traditional CAV scheme for patients with SCLC.

关 键 词：金喜素 顺铂 化疗 疗效 CAV方案 

分 类 号：S858.315.3[农业科学—临床兽医学]