KMG微球血管栓塞剂在部分性脾动脉栓塞治疗肝癌并脾功能亢进的临床应用评价  

Clinical application evaluation of partial splenic artery embolization with KMG microballoons for vascular occlusive agent

作　　者：蒙志斌[1] 马亦龙[1] 康平[1] 李志坤[1] 欧盛秋[1] 陈祖乾[1] 

机构地区：[1]广西医科大学附属肿瘤医院介入治疗科,广西南宁530021

出　　处：《海南医学》2007年第1期23-25,共3页Hainan Medical Journal

摘　　要：目的评价KMG微球作为栓塞材料在部分性脾栓塞术(PSE)治疗肝硬化脾功能亢进(脾亢)中的疗效及并发症。方法82例肝硬化脾亢行PSE患者,依据PSE术所采用的栓塞材料不同分为2组:A组44例,栓塞材料为明胶海绵联合栓塞材料:B组38例,栓塞材料为100—400μm的KMG微球。随访观察两组外周血白细胞、血小板和红细胞计数变化及术后反应。结果两组术后1年内白细胞和血小板计数均较术前明显升高(P<0.001)。虽然B组术后白细胞和血小板计数较A组升高较多,但两组的疗效差异无显著性(P>0.05)。两组术后红细胞计数一直无明显变化(P>0.05)。B组疼痛的程度重、持续时间长,而A组发热的发生率高。较严重并发症的发生率两组无明显差异。结论KMG微球可作为PSE术的栓塞材料,栓塞程度控制在50%～70%可有效治疗脾亢、减轻术后反应。Objective To evaluate the efficacy and complications of partial splenic embolization （PSE） using Polyvinyl Alcohol （KMG） microballoons as embolic material to treat the patients with hypersplenism and cirrhosis. Methods 100 patients with hypersplenism and cirrhosis were treated with PSE and followed up for 1 year, According to the differences of the embolic material in PSF, 82 patients were divided into 2 groups. Group A： 44 patients with spongia gelatinosa as the embolie material of PSE Group B： 38 patients with KMG microballoons （100-400μm） as the embolic material of PSE. The following up indices included counts variation of peripheral white blood cells （WBC）, peripheral blood platelets （PLT） and peripheral red blood cells （RBC） and the complications associatiated with PSE, Results In group A and group B, WBC and PLT counts kept obviously higher in number than pre-mbolization within 1 year （P〈0.001）. Though there is a higher increase of WBC and PLT connts after PSE in group B compared to group A, there is no significance differences of therapeutic effect between them （P〉0.05）. The RBC counts after PSE has no significant changes in both gronps constantly （P〉0.05）.The abdominal pain of group B was more serious and last a longer time, while group A has a higher incidence of fever. The occnrrence rate of more serious complications has no significant difference between the two groups. Conclusions KMG can be nscd as the embolic material for PSE with an effective treatment on hypersplenism and relieve of the reaction after PSE when the embolism degree is controlled from 50% to 70%.

关 键 词：脾功能亢进 肝硬化 栓塞 KMG微球 治疗性 

分 类 号：R657.63[医药卫生—外科学]