支原体肺炎血清急相蛋白水平变化及临床价值  

The Variation and Clinical Value of Serum Acute-phase Proteins about Mycoplasmal Pneumonia in Children

作　　者：尹志强[1] 韦凤[1] 刘月华[1] 

机构地区：[1]广东省东莞市莞城医院儿科,广东东莞523000

出　　处：《海南医学》2007年第1期44-45,共2页Hainan Medical Journal

摘　　要：目的探讨急相蛋白(APP)在支原体肺炎(MPP)患儿病程中的水平变化及价值。方法45例临床确诊的MPP患儿进入了该前瞻性的研究,对患儿病程急性期和恢复期的血清C反应蛋白(CRP)、α1酸性糖蛋白(α1-AGP)、触珠蛋白(HP)和铜兰蛋白(CP)水平进行了检测。结果急性期CRP,α1-AGP和HP均明显高于正常对照组,其差距具有统计学差异,P<0.05;CP仅轻微升高,P>0.05。恢复期4种APP均明显下降,其中CP已降至正常(P>0.05),其余3种APP仍高于正常(P<0.05)。急性期CRP、α1-AGP、HP及CP之间均呈正相关(P<0.05)。结论APP是反映MPP病程过程中的敏感指标,动态检测其水平变化对于判断病情转归和红霉素类药物的疗效有价值。Objective To investigate the variation and clinical value of serum acute-phase proteins（APP） about mycoplasmal pneumonia （MPP） in children. Methods There were 45 cases clinical definite MPP who were enrolled into this prospective research, whose C reactive protein （CRP）, α1-acid glycoprotein （α1-AGP）, haptoglobin （HP） and cemloplasmin （CP） were detected in acute phase and recovery phase. Results The level of CRP, α1-AGP and HP were higher in acute phase than that of normal control group, and the difference was significant. The level of CP increased but no statistics differance. All kinds of APP decreased obviously in recovery phase but still higher than normal except CP which has dropped to normal level. Conclusions APP are sensitive index which reflect the course of MPP, and it is valuable to detect the variation of APP for monitoring the turnover of MPP and guiding the applicantion of macrolides.

关 键 词：急性时相蛋白(APP) 支原体肺炎(MPP) C反应蛋白(CRP) 

分 类 号：R541.4[医药卫生—心血管疾病]