盐酸倍他洛尔片溶出度测定方法研究  

Studies on Dissolution Determination Method of Betaxolol Hydrochloride Tablets

作　　者：可钰[1] 魏爱卿[1] 张建业[1] 张广明[1] 刘宏民[1] 

机构地区：[1]郑州大学新药研究开发中心,郑州450052

出　　处：《河南师范大学学报（自然科学版）》2006年第4期84-86,共3页Journal of Henan Normal University(Natural Science Edition)

基　　金：国家自然科学基金(20272054);河南省重点攻关计划(423033600)

摘　　要：建立了盐酸倍他洛尔片溶出度的UV测定方法，并研究了盐酸倍他洛尔片的溶出曲线．UV检测波长为274nm，线性范围为40～140mg·L^-1，相关系数r=0．9998；平均加样回收率为99．91％，RSD为0．35％；连续进样精密度、8h溶液稳定性的RSD分别为0．02％、0．04％．该方法简便、快速、准确度高．UV analytical method on dissolution test of betaxolol hydrochloride tablets was developed, and the dissolution curve of the tablets were also studied. The detective wavelength was 274 nm. The linear range （the absorbance value against to the concentration of betaxolol hydrochloride） was from 40 mg·L^-1 to mg·L^-1, and the relative coefficient was 0. 9999. The average recovery of betaxolol hydroehloride was 99.91%, and its RSD was 0.35 %. The RSDs of continuously detections and detections per 2 hours in 8 hours were 0.02% and 0.04% respectively. It is a simple, convenient, quick and accurate analytical method for the analysis of betaxolol hydrochloride.

关 键 词：紫外可见分光光度法 盐酸倍他洛尔片 溶出度 

分 类 号：R917[医药卫生—药物分析学]