特比萘芬与复方酮康唑治疗皮肤真菌病疗效的比较  

Terbinafine vs compound ketoconazole in treating dermatomycosis

作　　者：马超[1] 牛丽敏[1] 李淑玲[1] 王伟[1] 吴玉红[1] 

机构地区：[1]阜阳市人民医院皮肤科,安徽阜阳236004

出　　处：《皮肤病与性病》2006年第4期6-8,共3页Dermatology and Venereology

摘　　要：目的特比萘芬与复方酮康唑治疗皮肤真菌病的疗效比较。方法患浅部真菌病病人60例,男性41例,女性19例,年龄(29±s9)A,随机分为特比萘芬组30例,应用特比萘芬软膏外涂患处,bid×2w;复方酮康唑组30例,外用复方酮康唑霜剂,bid×2w;在停药时及停药2w后观察疗效。结果治疗结束时,特比萘芬组总有效率为73%(22/30),复方酮康唑组为57%(17/30),P>0.05;停药2w后,特比萘芬组总有效率为97%(29/30),复方酮康唑组为47%(14/30),P<0.05。治疗结束时,特比萘芬组真菌清除率为83%,复方酮康唑组为53%,P<0.05,停药2w后,特比萘芬组真菌清除率为97%,复方酮康唑组为37%,P<0.01。2组均未见不良反应。结论特比萘芬治疗浅部真菌病优于复方酮康唑。Objective To compare the therapeutic effects of terbinafine and compound ketoconazole in treatment of dermatomycosis.Methods Sixty patients（ M41 ,F19,age 26 ±s9a） with derrnatomycosis were randomly divided into 2 groups. Thirty patients were treated with terbinafine, bid for 2wk. Thirty patients were treated with compound ketoconazole bid for 2wk, The drug effects were evaluated after the treatment. Results The total effective rates at the end of treatment were 73% （22/30） for terbinfine group and 57% （17/30） for compound ketoeonazole group（ P 〉0. 05） ;and 97% （29/30） for terbinafine group and 47% （14/30） for compound ketoconazole group（ P 〈0. 05 ） at 4 wk. Mycological clearance rates at 2 weeks were 83% for terbinafine group and 53% for compound ketoeonazole group（ P 〈0.05） ;and 97% for terbinafine group and 37% for compound kettoeonazolc group（ P 〈0. 01 ） at 4 weeks. There were no adverse reactions in both treatment groups. Conclusion Terbin-aline is better than compound ketoconazole in the treatment of dermatomycosis.

关 键 词：特比蔡芬 酮康唑 皮肤真菌病 局部投药 

分 类 号：R756[医药卫生—皮肤病学与性病学] R978.5[医药卫生—临床医学]