麻醉大鼠冰水灌耳交感神经响应在心血管调节中的作用  

Sympathetic Responses in Caloric Stimulation:Role in the Cardiovascular Control of Anesthetized Rats

作　　者：王林杰[1] 董卫军[1] 张丹[1] 赵琦[1] 仝飞舟[1] 曹毅[1] 

机构地区：[1]中国航天员科研训练中心,北京100094

出　　处：《航天医学与医学工程》2006年第6期403-407,共5页Space Medicine & Medical Engineering

基　　金：总装备部试验技术重点课题(01101307)

摘　　要：目的研究冰水灌耳刺激引起的交感神经响应、心率以及血压调节之间的内在联系,探讨前庭刺激在心血管调节中的作用。方法记录正常麻醉(CON)大鼠(n=5)、压力反射去除(SAD)大鼠(n=5)和迷路毁损(VD)大鼠(n=5)在冰水灌耳时内脏大神经传出放电及血压和心率的变化。结果正常麻醉大鼠灌耳后,血压、心率降低,内脏大神经反应由增强到减弱。压力反射去除大鼠灌耳后内脏大神经活动显著高于迷路毁损大鼠,且两组动物血压呈相反方向变化。内脏大神经放电与呼吸的耦合形式受到灌耳刺激的影响。结论半规管输入至少参与了血压的短时调节机制,其作用途径可能涉及呼吸运动的调节机制,在血压调节中压力反射和前庭输入两者作用不同,在某些生理调节过程中可能有协同作用。Objective To explore the potential connection between sympathetic response, heart rate and blood pressure modulation after caloric irrigation in order to study the role of vestibular stimuli in cardiovascular control. Method Efferent splanohnic nerve firing rates, ECG and blood pressure were recorded simultaneously during caloric stimuli on intact anesthetized（CON） rats（n = 5）, sinoaortic denervated （SAD） rats （ n = 5 ） and bilateral vestibular destroyed （VD） rats （ n = 5 ）. Result It was found that after caloric stimulation with ice water mean blood pressure CON rats with intact reflex became lower and the mean heart rates became slower, splanchnic sympathetic nerve activities in- creased for a moment and then dropped significantly. SAD rats had significant stronger splanchnic sympathetic nerve activities VD rats after caloric stimulation, and their blood pressures changed to apposite directions. The coupled respiratory component on splanhnic sympathetic nerve activities were strongly affected by the caloric stimulation. Conclusion It is suggested that semicircular canal stimulation participate at least in the short-term blood pressure control mechanism and the role of central nervous system on respiratory drive may also be involved. Baro-reflex and vestibular afferent may play different role in the control of blood pressure they may work synergically in some physiological control processed.

关 键 词：交感神经响应 心血管调节 灌耳刺激 血压调节 心率 

分 类 号：R852.5[医药卫生—航空、航天与航海医学]