葡聚糖磁流体皮下注射的安全性评价  

Security Evaluation of Subcutaneous Injection with Water-based Dextran-coated Magnetic Fluid

作　　者：翟羽[1] 王晓亮[1] 王煦漫[1] 谢弘[2] 古宏晨[1] 

机构地区：[1]上海交通大学纳米科学与技术工程中心,上海200030 [2]中国科学院生物化学与细胞生物学研究所,上海200031

出　　处：《生物医学工程学杂志》2006年第6期1275-1278,共4页Journal of Biomedical Engineering

基　　金："863"资助项目(2002AA302210);上海市纳米专项资助项目(0249nm071)

摘　　要：用50%葡聚糖40000水溶液包覆纳米铁氧体粒子制备磁流体,观察磁流体皮下注射引起的急性毒性和刺激性。葡聚糖磁流体注射小鼠皮下,LD50为4409.61±514.93mg/kg。皮下注射30mg/0.3ml葡聚糖磁流体24h后可见皮下血管扩张和注射部位的白细胞浸润,72h后反应基本消失。注射30mg/0.3ml油酸钠磁流体后7d左右可引起注射部位皮肤溃破、脱落。结果表明,葡聚糖磁流体皮下注射安全、可以耐受,而油酸钠磁流体不宜皮下注射。Water-based magnetic fluid was synthesized by using 50 % dextran 40000 as coated reagent. The acute toxicity and irritant of the magnetic fluid injected into mice subcutaneous tissues were examined. The lethal dosage 50 of dextran-coated magnetic fluid was 4409. 61 ±514. 93 mg/kg. Twenty four h after subcutaneous injecting with 30 mg/0. 3 ml dextran-coated magnetic fluid, no more inflammation than hemangiectasia and leucocytes infiltration had been seen in subcutaneous tissues, 72 h later the reaction phenomena disappeared. While, injection with 30 mg/0.3 ml water-based oleate sodium-coated magnetic fluid, ulceration and break-off of cutis had been seen in the seventh days. That is to say, the dextran-coated magnetic fluid was safe and well tolerate, however, the oleate sodium-coated magnetic fluid was not fit to subcutaneous injection.

关 键 词：葡聚糖 磁流体 急性毒性 刺激性 皮下注射 

分 类 号：R318.08[医药卫生—生物医学工程]