乌司他丁对脓毒性休克患者细胞因子的影响  

The effect of Ulinastatin on the delivery of cytokines in patients with septic shock

作　　者：蒋龙元[1] 杨炼红[2] 常建星[1] 何志捷[1] 余涛[1] 黄子通[1] 

机构地区：[1]中山大学附属第二医院急诊科,广州510120 [2]中山大学附属第二医院神经科,广州510120

出　　处：《中华急诊医学杂志》2006年第12期1136-1138,共3页Chinese Journal of Emergency Medicine

基　　金：广东省科技计划项目(2004B30601001)

摘　　要：目的探讨乌司他丁(UTI)对脓毒性休克患者细胞因子的影响。方法采用前瞻对照研究。78例脓毒性休克患者随机分为对照组和治疗组各39例,两组均行常规抗休克和病因治疗。治疗组用乌司他丁20万U溶于20 ml 0．9%生理盐水中静脉注射,每24 h一次,连续3 d；对照组则以等量生理盐水作为安慰对照。分别于不同时相(静脉注射UTI前、后24 h、48 h和72 h)测试血清肿瘤坏死因子-α(TNF-α)、IL-1、IL-6、IL-8和SOD水平。结果与对照组相比,治疗组应用乌司他丁后不同时相点的TNF-α、IL-1、IL- 6、IL-8均明显降低(P＜0．05,P＜0．01),而SOD显著增加(P＜0．05,P＜0．01)。结论乌司他丁可降低脓毒性休克患者TNF-α、IL-1、IL-6和IL-8的水平并提高SOD活性,从而达到保护器官的作用。Objective To investigate the effect of Ulinastatin on the delivery of cytokines in patients with septic shock. Methods It was a prospective and controlled clinical study. Seventy-eight patients with septic shock were randomly divided into control group and treatment group and thirty-nine in every group. Patients in treatment group received Ulinastatin 200 000 units intravenous everyday for 3 days, while those in control group received equal volume of normal saline as placebo. At different time points （ at 24 th, 48 th, 72 th hour after start of treatment ）, the levels of tumor necrosis factor-alpha （ TNF-α）, interleukin-1 （ IL-1 ）, interleukin-6 （IL-6）, interleukin-8 （ IL-8 ） and superoxide dismutase （SOD） in serum were assayed. Results In comparison with control group, the levels of TNF-α, IL-1, IL-6, IL- 8 of treatment group decreased markedly （ P 〈 0.05, P 〈 0.01 ） at different time points, whereas the level of SOD was higher markedly （ P 〈 0.05, P 〈 0.01 ） at various time points. Conclusion Ulinastatin has protective effect on patients with septic shock through decreasing the levels of TNF-α, IL-1, IL-6, IL-8 and increasing in the level of SOD.

关 键 词：乌司他丁 脓毒性休克 细胞因子 

分 类 号：R459.7[医药卫生—急诊医学]