EMS患者血清、腹腔液TGF-β、IGF-Ⅰ、TNF-α及IL-8水平测定  

Clinical Singnificance of Determination of Changes of Serum and Peritoneal Fluid TGF-β,IGF-Ⅰ,TNF-α and IL-8 Levels in Patients with Endometriosis

作　　者：赵雨花[1] 张菊红[2] 马云宝[2] 

机构地区：[1]扬州大学医学院附属常熟市第二人民医院妇产科,215500 [2]扬州大学医学院附属常熟市第二人民医院核医学科,215500

出　　处：《放射免疫学杂志》2006年第6期457-459,共3页Journal of Radioimmanology

摘　　要：目的探讨EMS患者血清、腹腔液中TGF-β、IGF-Ⅰ、TNF-α及IL-8水平测定的意义。方法应用放射免疫分析测定了30例EMS患者及30名对照组血清、腹腔液中TGF-β、IGF-Ⅰ、TNF-α及IL-8水平。结果EMS患者血清、腹腔液中的4项指标均显著高于对照组(P均<0.05),且EMS患者腹腔液中的水平明显高于血清(P<0.05)。结论4项指标的变化可表明,它们在EMS的生理病理过程中起了一定的作用。Objective To investigate the clinical significance of the changes of serum and peritioneal fluid TGF-β、IGF-Ⅰ、TNF-α and IL-8 levels in patients with endometriosis. Methods Serum and peritoneal fluid levels of TGF-β、IGF-Ⅰ、TNF-α and IL-8 were measured with RIA in 30 patients with endometriosis and 30 controls. Results The levels of TGF-β、IGF-Ⅰ、TNF-α and IL-8 in serum and peritoneal fluid in endometriosis group were significantly higher than those in the controls （P 〈 0. 05）, moreover, the levels of the markers in peritoneal fluid were significantly higher than those in serum （P 〈0.05 ）. Conclusion It is likely that elevation of serum and peritoneal fluid levels of the markers may play a role in the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 转化生长因子-Β 胰岛素样生长因子-Ⅰ 肿瘤坏死因子-α 白细胞介素-8 

分 类 号：R71[医药卫生—妇产科学]