皮肤外用纳米马钱子碱脂质体的镇痛抗炎作用  

Analgesic and anti-inflammatory activities of brucine nano-liposome for local use on skin

作　　者：简江波[1] 袁媛[2] 杨柏灿[1] 刘昌胜[2] 

机构地区：[1]上海中医药大学中药学院中药教研室,上海201203 [2]教育部生物医学工程研究中心华东理工大学生物材料研究所,上海200237

出　　处：《中成药》2006年第12期1778-1781,共4页Chinese Traditional Patent Medicine

基　　金：上海市科学技术委员会纳米专向资助项目(0352nm115)

摘　　要：目的:考察纳米马钱子碱脂质体局部外用的镇痛及抗炎效果,并同马钱子碱、马钱子碱和纳米脂质体的机械混合溶液进行了比较。方法:采用耳肿胀法和扭体法研究并比较了纳米马钱子碱脂质体和马钱子碱对二甲苯所致急性炎症及醋酸所致扭体反应的抑制效果。结果:纳米马钱子碱脂质体对炎症和疼痛均有明显的抑制作用,优于未经脂质体包裹的马钱子碱(P<0.01)。结论:纳米脂质体化可以显著提高皮肤外用马钱子碱的镇痛和抗炎效果,是马钱子碱皮肤局部外用制剂的良好载体。AIM ： To compare brucine with the mixed solution of brucine and nano-liposomes to observe analgesic and anti-inflammatory effects of the brucine nano-liposome for local use on skin were studied. METHODS ： The effects of brucine, brucine and nano-liposomes mixed solution, brucine nano-liposome, on the edema of mouse ear induced by dimethylbenzene and the writhing induced by acetic acid were investigated. RESULTS： The results showed that brucine nano-liposomes exhibited better anti-inflammatory and analgesic activities than the brucine. （P 〈 0.01 ）. CONCLUSION： Liposome is an effective carrier for the local use on skin of brucine.

关 键 词：马钱子碱 纳米脂质体 镇痛 抗炎 

分 类 号：R285.6[医药卫生—中药学]