间乙酰氨基苯胺的HPLC分析  

Determination of m - Aminoacetanilide by HPLC

作　　者：王秀英[1] 

机构地区：[1]天津大学化学工程研究所,天津300073

出　　处：《染料工业》1996年第5期38-39,共2页Dyestuff Industry

基　　金：国家重点化学工程联合实验室资助项目

摘　　要：本文提出测定间已酰氨基苯胺(1)及其杂质N,N-二乙酰替间苯二胺(2)和间苯二胺(3)高效液相色谱(HPLC)的分析方法.高效液相色谱采用的色谱柱为Waters μ-BondaPak Phenvl柱(ф6×150mm),流动相为甲醇-水(75:25),紫外检测器UV的检测波长为245um.变异系数对于(1)、(2)、(3)分别为0.82%、0.95%、和0.72%,回收率分别为99.5%、99.7%和99.1%.In this paper the dye intermediate, m - aminoacetanilide(1), and its by - products, N, N - diacetyl - 1, 3- diaminobenzene(2)and 1,3 - diaminobenzene(3), were determined by HPLC using a column of Waters μ - Bondapak Phenyl(Φ6 ×150mm), the mobile phase of a mixture of methanol and water in volume ratio 75 : 25 and a UV detector at 245nm. The coefficients of variation for the components (1), (2)and (3)are0.82%, 0.95%, and 0.72% respectively, and their recoveries are 99.5%, 99.7% and 99.1 % respectively.

关 键 词：间乙酰氨基苯胺 高效液相色谱 

分 类 号：TQ246.3[化学工程—有机化工]