血清腹水白蛋白梯度的临床应用价值  

Clinical application value of serum ascites albumin gradient

作　　者：祁小鸣[1] 解正林[1] 毛志东[1] 张焕明[1] 杨永年[1] 

机构地区：[1]南京医科大学第三附属医院消化内科,江苏仪征211900

出　　处：《临床和实验医学杂志》2006年第12期1910-1911,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的研究血清腹水白蛋白梯度(SAAG)在腹水性质鉴别中的的临床应用价值。方法选择诊断明确的腹水患者72例,分为门脉高压组40例、非门脉高压组32例,分别测定其血清与腹水中总蛋白和白蛋白的值并进行比较。结果门脉高压组患者SAAG为(19.18±5.22)g/L,非门脉高压组患者SAAG为(7.82±3.12)g/L,两组比较差异有显著性意义(P<0.001)。SAAG对门脉高压诊断的敏感度95%(38/40),特异度96.9%(31/32),准确度95.8%(69/72),阳性预测值97.4%(38/39),阴性预测值93.9%(31/33),均明显高于腹水总蛋白诊断渗、漏出液分类方法。结论血清腹水白蛋白梯度对鉴别门脉高压性腹水和非门脉高压性腹水具有重要的临床价值,值得临床推广应用。Objective To research the clinical application value of serum aseites albumin gradient （SAAG） to differentiate the properties of ascites. Methods 72 patients with aseites fluid were retrospectively collected from patients with characterized causes of ascites. Patients were divided into two groups： portal hypertension group 40 cases,nonportal hypertension group 32 cases. To test the total albumin and albumin in serum and ascites and analyze these parameters. Results The mean concentration of SAAG of portal hypertension group （ 19.18 ± 5.22） g/L waS significanfly higher than that of nonportal hypertension gToup （7.82 ± 3.12 ） g/L, P 〈 0.001. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of SAAG diagnose portal hypertension were 95% （38/40）, 96.9% （31/32） ,95.8% （69/72）, 97.4% （ 38/ 39） and 93.9% （3l/33 ） respectively. All these indexes were significant higher than ascites fluid total protein in the diagnosis that used exudates and transudates. Conclusion There are significant clinical value for SAAC which identify ascites fluid of portal hypertension from nonportal hypertension ,it is worth to popularize.

关 键 词：血清腹水白蛋白梯度 总蛋白 门脉高压 

分 类 号：R446.11[医药卫生—诊断学]