链激酶研究概况及其进展  

General Situation and Latest Progress on Streptokinase

作　　者：张华山[1] 闫俊鹏[2] 齐义鹏[2] 李亚芳[1] 余响华[1] 

机构地区：[1]湖北工业大学生物工程学院,武汉430068 [2]武汉大学生命科学学院,武汉430072

出　　处：《氨基酸和生物资源》2006年第4期71-73,共3页Amino Acids & Biotic Resources

摘　　要：链激酶(Streptok inase,SK)是世界上最早发现的纤维蛋白酶原激活剂,也是最早作为临床药品治疗血栓性疾病的溶栓酶。它是由A,C,G群链球菌中β-溶血性链球菌分泌的胞外非酶蛋白质,能和纤溶酶原结合,将纤溶酶原激活为纤溶酶,具有溶解血栓的作用。本文详细综述了该酶的性质、在溶栓酶中的地位、研究历史、作用机理等。此外,由于它有半衰期短、不具有纤维蛋白特异性、治疗后出血和血栓易复发的缺点,所以有必要用基因工程的手段进行改造,以达到更好的治疗效果。Streptokinase （SK） was discovered as the first plasminogen activator in the world, and it was the earliest clinical agent to cure thrombus. Streptokinase is an extracellular protein which is produced by β - hemolytic streptococci group A, C and G. It binds to plasminogen （Pg） to form a complex that converts substrate Pg to plasmin. And it can lyse blood clots. We summarized the characteristics,status,research history,catalytic mechanism of it. In addition, Because of its short half- life,bleeding,non fibrin - specific and recurring rate, it is necessary to reconstruct it by gene engineering to obtain better curative effect.

关 键 词：链激酶 重组链激酶 纤溶酶原 

分 类 号：Q936[生物学—微生物学]