血脂及增龄对2型糖尿病合并冠心病患者血管造影及微量蛋白尿的影响  

Influence of serum lipids and ageing on coronary angiographic characteristics and microalbuminuria in type 2 diabetic patients with coronary heart disease

作　　者：宫建丽[1] 孔香云[1] 唐侠[2] 李文华[1] 张秀洲[1] 唐元升[1] 朱兴雷[1] 

机构地区：[1]山东省立医院,老年及心血管内科,济南市250021 [2]山东省立医院眼科,济南市250021

出　　处：《中华老年多器官疾病杂志》2006年第3期201-203,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：山东省卫生科技发展计划(2003-35)

摘　　要：目的探讨血脂及增龄对2型糖尿病合并冠心病患者血管造影及微量蛋白尿的影响。方法按年龄、血脂及年龄与血脂分组,对203例2型糖尿病合并冠心病患者的血管造影及微量蛋白尿资料进行对比分析。结果与<60岁组相比,≥60岁组冠状动脉四支血管病变及左主干(LM)受累多,糖尿病性视网膜病变(DR)严重,24h尿微量蛋白定量高;TC异常组与TC正常组相比,CAG、FFA及24h尿微量蛋白定量结果的差异无统计学意义。年龄与血脂进行交叉分组对比分析,TC正常高龄组较TC异常低龄组冠状动脉四支血管病变及LM受累多,DR严重,24h尿微量蛋白定量高。结论TC降低不能改变2型糖尿病合并冠心病患者血管病变及微量蛋白尿特征随增龄而改变的趋势。Objective To study the influence of serum lipids and ageing on angiographic characteristics and microalbuminuria in type 2 diabetes mellitus patients with CHD. Methods The data of selective coronary angiography, fundus fluorescence angiography（FFA） and microalbuminuria in 203 type 2 diabetes mellitus patients with CHD were analyzed. The patients were divided into different groups by age and lipid levels. Results Compared with 〈 60 year group, 960 year group had more four-vessel coronary artery disease, more left main coronary artery（LM） involvement, more severe diabetic retinopathy（DR） and higher 24-hour microalbumin quantity in urine. The difference in angiographic characteristics and microalbuminuria between different lipid level groups was not significant. Crossed analysis of different age and lipid level groups suggested that patients with higher age and normal lipid level had more four coronary artery disease, more LM involvement, more severe DR and higher 24-hour microalbumin quantity in urine than patients with lower age and abnormal lipid level. Conclusions Decrease in total cholesterol can not alter the trend of the change in angiographic lesions and microalbuminuria with ageing.

关 键 词：糖尿病 非胰岛素依赖型 冠心病 高脂血症 年龄因素 冠状动脉造影 眼底荧光血管造影 微量蛋白尿 

分 类 号：R587.1[医药卫生—内分泌]