HCV不同功能区抗体与HCVRNA的关系探讨  

Relationship between anti-bodies for different regions of HCV and HCV RNA.

作　　者：丁贤[1] 邵新华[1] 周淑芬[1] 

机构地区：[1]天津市第三中心医院检验科,天津300170

出　　处：《临床肝胆病杂志》2006年第6期431-432,共2页Journal of Clinical Hepatology

摘　　要：探讨HCV不同功能区抗体(抗-C、抗-NS3、抗-NS4及抗-NS5)与HCVRNA的关系。HCV不同功能区抗体测定采用ELISA法,用RT-PCR进行HCV RNA检测。结果显示55例抗HCV阳性血清中有7种抗体阳性组合。抗-NS3、抗-C、抗-NS5及抗-NS4在7种阳性组合中的检出率分别为96．4%、89．1%、58．2%、56．4%。HCVRNA阳性血清中抗-NS3、抗-C、抗-NS5及抗NS4的检出率分别为96．2%,88．5%,57．7%,57．7%。HCV不同功能区抗体ELISA法有很高的敏感性和特异性,与RT-PCR法基本一致。抗-NS3、抗-C在HCV的诊断中有重要的意义,抗-NS5和抗-NS4有诊断的互补作用。To investigate the relationship between anti - bodies for different regions of HCV （anti - c, anti - NS3, anti - NS4 and anti - NS5 ） and HCV RNA. Different region antibodies of HCV were detected by ELISA, and HCVRNA detected by RT - PCR. There were seven positive groups in 55 cases with anti - HCV positive. The positive rates of anti - NS3, anti - C, anti - NS5 and anti - NS4 in the seven positive group were 96. 4% , 89. 1% , 58. 2% , and 56. 4% respectively. The positive rates of anti - NS3, anti - C, anti - NS5 and anti - NS4 in serum with HCVRNA positive were 96.2%, 88.5%, 57.7% and 57.7% separately. Anti - HCV different region ELISA has the same sensitivity and specificity as that of RT - PCR. Anti - NS3 and anti - C were very important to diagnose HCV. anti - NS5 and anti - NS4 had mutually complementary effect in diagnosing HCV.

关 键 词：丙型肝炎病毒 不同功能区抗体 丙型肝炎病毒RNA 

分 类 号：R512.63[医药卫生—内科学]