血清瘦素水平与冠状动脉病变程度的关系  

Relationship between serum leptin concentration and angiographic characteristics of coronary atherosclerosis

作　　者：王丽[1] 赵勇[1] 陈娟[2] 周洁[2] 曾和松[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院心内科,武汉430030 [2]华中科技大学同济医学院分子生物教研室

出　　处：《临床心血管病杂志》2006年第12期719-720,共2页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助项目(No:30470713)

摘　　要：目的:探讨血清瘦素水平与冠状动脉病变程度的关系。方法:用放射免疫法检测冠状动脉造影确诊的冠心病患者101例(男59例,女42例)及与其年龄,性别及体质指数相匹配的健康体检者96例(男50例,女46例)的血清瘦素水平。用改良的Gensini评分系统对冠状动脉病变程度进行评分。结果:冠心病组无论男女,血清瘦素水平均显著高于对照组[(8.43±4.29)∶(4.34±2.15)μg/L、(15.87±8.07)∶(8.36±3.81)μg/L](P<0.01)。随着冠状动脉病变程度的加重,冠心病患者血清瘦素水平逐渐升高。Gensini积分为11的患者与积分为5的患者之间血清瘦素水平差异有统计学意义[(12.90±0.92)∶(8.44±0.57)μg/L,P<0.05]。结论:冠心病患者的血清瘦素水平明显高于健康者,并随着冠脉病变程度的增加而升高。Objective：To explore the relationship between serum leptin concentration and angiographic characteristic of coronary atherosclerosis. Method：One hundred and one coronary heart disease （CHD） patients who identified by coronary angiography and 96 healthy control subjects were recruited in this study . The angiographic characteristic of coronary artery atherosclerosis was defined with the method of modified Gensini score. The serum leptin concentration of the CHD group and the control group were measured by radioimmunoassay. Result：The serum leptin concentration in the CHD group was significantly higher than those in the control group [（8.43±4.29）：（4.34±2.15）μg/L, （15. 87±8. 07） ： （8.36±3.81）μg/L]（P〈0.01）. With the development of atherosclerosis, the leptin concentration was increased. There was significant difference between Gensini score 11 and 5 （[12. 90±0.92] vs [8.44±0.57]μg/L, P〈0.05）. Conclusion： The leptin concentration of the CHD group is significantly higher than those of the control group, and is related to the severity of atherosclerosis positively.

关 键 词：冠状动脉疾病 瘦素 

分 类 号：R543.3[医药卫生—心血管疾病]