紫外光谱研究β-环糊精衍生物对R／S-扁桃酸的包结作用  

On inclusion mechanics betweenβ-cyclodextrin and R/S-mandelic acid

作　　者：唐课文[1] 张国丽[2] 

机构地区：[1]湖南理工学院化学化工系,湖南岳阳414000 [2]中南大学化学化工学院,湖南长沙410083

出　　处：《湖南理工学院学报（自然科学版）》2006年第4期47-50,共4页Journal of Hunan Institute of Science and Technology(Natural Sciences)

基　　金：国家自然科学基金项目(20376085)

摘　　要：利用紫外光谱法研究了系列β-环糊精衍生物(羟丙基β-环糊精1、羟乙基β-环糊精2和甲基β-环糊精3)时R／S-扁桃酸的包结作用,考察了各β-环糊精衍生物浓度对包结行为的影响。研究结果表明扁桃酸与各β-环糊精衍生物形成的包合物的包结比为1:1,三种主体环糊精的包结能力强弱顺序为:1>2>3,对于同一主体而言,R-扁桃酸比S-扁桃酸易于被包合,且Ks/KR的顺序与K值的次序有所差别:2>1>3。同时,以羟丙基β-环糊精作为主体研究了客体扁桃酸的存在形态对包结作用的影响,结果表明羟丙基β-环糊精适合包结中性扁桃酸分子,不宜包结扁桃酸离子。The inclusion of derivatives of β-cyclodextrin （ HP-β-CD1, HE-β-CD2, Me-β-CD3 ） with R/S-mandelic acid in aqueous solution has been studied using UV spectrophotometry. Effects of β-cyclodextrin concentration on inclusion behavior have been investigated, The results indicate that mandelic acids and derivatives of β-cyclodextrin complex with 1：1 molar ratio is formed The order of binding ability of three hosts with mandelic acids is： 1〉3〉2. R-mandelic acid is easier to be complexed by CD than S-mandelic acid, and the order of KR/KS differing from that of association constant values is： 2〉1〉3, In addition, we selected HP-β-CD as host and investigated the effects of presence state of mandelic acid on inclusion, The results show that HP-β-CD is more suitable to complex with molecular state than ironic state.

关 键 词：扁桃酸对映体 Β-环糊精衍生物 包结作用 紫外光谱 

分 类 号：O636.12[理学—高分子化学]