肺癌患者围手术期细胞免疫功能的变化  

The perioperative changes of cellular immune function in lung cancer patients

作　　者：叶凤青[1] 秦丹丹[1] 宁加娟[2] 林发全[2] 

机构地区：[1]广西壮族自治区人民医院麻醉科,南宁市530021 [2]广西医科大学第一附属医院检验科

出　　处：《中国医学文摘（肿瘤学）》2006年第4期371-372,共2页Journal of Chinese Medical Abstracts·Oncology

基　　金：广西自然科学基金资助课题（桂科青0339020）

摘　　要：目的 探讨肺癌患者围手术期外周血T细胞亚群和NK细胞的变化及意义。方法 应用流式细胞仪检测20例肺癌患者和20例肺良性肿瘤患者手术前、术后第1天和第7天外周血T细胞亚群和NK细胞活性的变化。结果 肺癌组术前CD。3^＋、CD4^＋、CD4^＋／CD8^＋和NK细胞活性均低于肺良性肿瘤组（P〈0．01）肺癌组病人行病灶切除术后1d，CD3^＋、CD4^＋和CD4^＋／CD矿较术前降低（P〈0.01）．术后1w上述指标较术盯升高（P〈0．01），而NK细胞活性在术后ld升高（P〈0．01）．术后1w与术前相似（P〉0．05）。结论 肺癌患者的细胞免接功能低于肺良性肿瘤患者；肺癌患者术后的免疫状态呈现先降后升的变化，切除病灶能显著提高患者的免疫功能。Objective To explore the perioperative changes of T subsets and natural killer cell and analyze the related factors in patients with lung cancer. Methods The T subsets and natural killer cell active from peripheral blood of 20 patients with lung cancer, 20 patients with lung benign tumor were measured respectively by flow cytometry preoperatively, 1 day and 7 days after surgery. Results There were significant differences in the indexes between the lung cancer group and the groups of lung benign tumor group patients before operation （P 〈 0. 01 ）. At postoperative 1 day, CD3^＋ , CD4^＋ and CD4^＋ / CD8^＋ of the patients with lung cancer were decreased significantly than those be fore operation （P 〈0. 01 ） , while at postoperative 7 day were increased significantly （P 〈0. 01 ）. But at postoperative 1 day, NK cel 1 active of the patients with lung cancer was increased than those before operation （P〈 0. 01 ） , there was no difference in those between preo peration and at postoperative 7 day. Conclusions The cellular immune function of the patients with lung cancer was lower than that of the patients with lung benign tumor. The perioperative immunity of patients with lung cancer decreases after operation and increases later, radical operation can significantly increase the patients＂ cellular immune function.

关 键 词：肺肿瘤 T细胞亚群 NK细胞 外科治疗 围手术期 

分 类 号：R473.73[医药卫生—护理学]